Macrophages isolated from chickens genetically resistant or susceptible to systemic salmonellosis show magnitudinal and temporal differential expression of cytokines and chemokines following Salmonella enterica challenge

Paul Wigley, Scott Hulme, Lisa Rothwell, Nat Bumstead, Pete Kaiser, Paul Barrow

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those from susceptible birds. This suggests the possibility that salmonellosis resistant-line macrophages signal more effectively and rapidly and are more able to induce protective Th1 adaptive responses.
Original languageEnglish
Pages (from-to)1425-30
Number of pages6
JournalInfection and Immunity
Volume74
Issue number2
DOIs
Publication statusPublished - 2006

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