Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study

Maria-eleni Dounavi; Coco Newton; Natalie Jenkins; Elijah Mak; Audrey Low; Graciela Muniz-terrera; Guy B. Williams; Brian Lawlor; Lorina Naci; Paresh Malhotra; Clare E. Mackay; Ivan Koychev; Karen Ritchie; Craig W. Ritchie; Li Su; John T. O’brien

doi:10.1007/s00415-022-11061-7

Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study

Maria-eleni Dounavi, Coco Newton, Natalie Jenkins, Elijah Mak, Audrey Low, Graciela Muniz-terrera, Guy B. Williams, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare E. Mackay, Ivan Koychev, Karen Ritchie, Craig W. Ritchie, Li Su, John T. O’brien

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of Neurology
Early online date	13 Mar 2022
DOIs	https://doi.org/10.1007/s00415-022-11061-7
Publication status	E-pub ahead of print - 13 Mar 2022

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10.1007/s00415-022-11061-7

Dounavi2022_Article_MacrostructuralBrainAlterationFinal published version, 1.29 MBLicence: Creative Commons: Attribution (CC-BY)

https://link.springer.com/10.1007/s00415-022-11061-7

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Dounavi, M., Newton, C., Jenkins, N., Mak, E., Low, A., Muniz-terrera, G., Williams, G. B., Lawlor, B., Naci, L., Malhotra, P., Mackay, C. E., Koychev, I., Ritchie, K., Ritchie, C. W., Su, L., & O’brien, J. T. (2022). Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study. Journal of Neurology. https://doi.org/10.1007/s00415-022-11061-7

@article{2d31d17df5814da4bc5f6069a13a7f41,

title = "Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study",

author = "Maria-eleni Dounavi and Coco Newton and Natalie Jenkins and Elijah Mak and Audrey Low and Graciela Muniz-terrera and Williams, {Guy B.} and Brian Lawlor and Lorina Naci and Paresh Malhotra and Mackay, {Clare E.} and Ivan Koychev and Karen Ritchie and Ritchie, {Craig W.} and Li Su and O{\textquoteright}brien, {John T.}",

note = "Funding Information: This work was funded by grants for the PREVENT-Dementia program from the UK Alzheimer's Society (Grant nos. 178, 264 and 397). The PREVENT-Dementia study is also supported by the US Alzheimer's Association (Grant no. TriBEKa-17–519007) and philanthropic donations. LS is supported by the Cambridge NIHR Biomedical Research Center (BRC) and Alzheimer's Research UK (ARUK-SRF2017B-1). JOB receives infrastructural support from the Cambridge NIHR BRC. Funding Information: This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We would also like to acknowledge the PREVENT-Dementia participants, the DeNDRoN specialty within the Clinical Research Network. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = mar,

day = "13",

doi = "10.1007/s00415-022-11061-7",

language = "English",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "D. Steinkopff-Verlag",

}

Dounavi, M, Newton, C, Jenkins, N, Mak, E, Low, A, Muniz-terrera, G, Williams, GB, Lawlor, B, Naci, L, Malhotra, P, Mackay, CE, Koychev, I, Ritchie, K, Ritchie, CW, Su, L & O’brien, JT 2022, 'Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study', Journal of Neurology. https://doi.org/10.1007/s00415-022-11061-7

TY - JOUR

T1 - Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study

AU - Dounavi, Maria-eleni

AU - Newton, Coco

AU - Jenkins, Natalie

AU - Mak, Elijah

AU - Low, Audrey

AU - Muniz-terrera, Graciela

AU - Williams, Guy B.

AU - Lawlor, Brian

AU - Naci, Lorina

AU - Malhotra, Paresh

AU - Mackay, Clare E.

AU - Koychev, Ivan

AU - Ritchie, Karen

AU - Ritchie, Craig W.

AU - Su, Li

AU - O’brien, John T.

N1 - Funding Information: This work was funded by grants for the PREVENT-Dementia program from the UK Alzheimer's Society (Grant nos. 178, 264 and 397). The PREVENT-Dementia study is also supported by the US Alzheimer's Association (Grant no. TriBEKa-17–519007) and philanthropic donations. LS is supported by the Cambridge NIHR Biomedical Research Center (BRC) and Alzheimer's Research UK (ARUK-SRF2017B-1). JOB receives infrastructural support from the Cambridge NIHR BRC. Funding Information: This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We would also like to acknowledge the PREVENT-Dementia participants, the DeNDRoN specialty within the Clinical Research Network. Publisher Copyright: © 2022, The Author(s).

PY - 2022/3/13

Y1 - 2022/3/13

U2 - 10.1007/s00415-022-11061-7

DO - 10.1007/s00415-022-11061-7

M3 - Article

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

ER -