Abstract
Partial volume mixing of water compartments within a spectroscopy voxel (e.g. cerebrospinal fluid within a "brain" voxel) may, if not corrected for, lead to underestimation of brain metabolite concentrations, To correct for this source of bias, a new imaging-based method of compartmentation analysis is presented. Brain water, cerebrospinal fluid and solid matter content were obtained from proton density- and T-2-weighted images of the brain and an external standard in 10 healthy young males (21 to 30 years), and results compared with a previously-described technique based on spectroscopy. Mean (SD) fractional water content (beta(MR)) Of the 2 x 2 x 2 cm3 voxel in the frontal lobes was 0.79 (0.03) by imaging, slightly but significantly (p = 0.03) smaller than the value of 0.83 (0.03) obtained by spectroscopy. From water-suppressed spectra recorded at five echo times, using beta(MR) determined by imaging, the T-2-corrected concentrations of compounds containing N-acetylaspartate, creatine, choline and myo-inositol were 10.6 (1.0), 8.0 (0.9), 1.6 (0.3) and 3.7 (0.7) mmol.l(-1) of brain, respectively. Imaging-based compartmentation is a rapid and straightforward technique, and can be performed on standard MR systems. Magn Reson Med 41:883-888, 1999. (C) 1999 Wiley-Liss, Inc.
Original language | English |
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Pages (from-to) | 883-888 |
Number of pages | 6 |
Journal | Magnetic Resonance in Medicine |
Volume | 41 |
Issue number | 5 |
Publication status | Published - May 1999 |
Keywords / Materials (for Non-textual outputs)
- compartmentation
- frontal lobe
- imaging
- spectroscopy
- HUMAN-BRAIN
- ABSOLUTE QUANTITATION
- MR SPECTROSCOPY
- QUANTIFICATION
- INVIVO
- WATER
- CALIBRATION
- CONTRAST
- SPECTRA
- SIGNALS