Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

Angela C. C. Jochems; Susana Muñoz Maniega; Una Clancy; Carmen Arteaga; Daniela Jaime Garcia; Francesca M. Chappell; Will Hewins; Rachel Locherty; Ellen V. Backhouse; Gayle Barclay; Charlotte Jardine; Donna McIntyre; Iona Gerrish; Agniete Kampaite; Eleni Sakka; Maria Valdés Hernández; Stewart Wiseman; Mark E. Bastin; Michael S. Stringer; Michael J. Thrippleton; Fergus N. Doubal; Joanna M. Wardlaw

doi:10.1161/JAHA.123.032259

Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

Angela C. C. Jochems, Susana Muñoz Maniega, Una Clancy, Carmen Arteaga, Daniela Jaime Garcia, Francesca M. Chappell, Will Hewins, Rachel Locherty, Ellen V. Backhouse, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Agniete Kampaite, Eleni Sakka, Maria Valdés Hernández, Stewart Wiseman, Mark E. Bastin, Michael S. Stringer, Michael J. ThrippletonFergus N. Doubal, Joanna M. Wardlaw^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of the American Heart Association
DOIs	https://doi.org/10.1161/JAHA.123.032259
Publication status	Published - 31 Jan 2024

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10.1161/JAHA.123.032259

jochems-et-al-2024-magnetic-resonance-imaging-tissue-signatures-associated-with-white-matter-changes-due-to-sporadicFinal published version, 4.06 MBLicence: Creative Commons: Attribution (CC-BY)

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Jochems, A. C. C., Maniega, S. M., Clancy, U., Arteaga, C., Garcia, D. J., Chappell, F. M., Hewins, W., Locherty, R., Backhouse, E. V., Barclay, G., Jardine, C., McIntyre, D., Gerrish, I., Kampaite, A., Sakka, E., Hernández, M. V., Wiseman, S., Bastin, M. E., Stringer, M. S., ... Wardlaw, J. M. (2024). Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress. Journal of the American Heart Association. https://doi.org/10.1161/JAHA.123.032259

@article{133d0eee33ae43af8e2fa5e0c6f23eac,

title = "Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress",

author = "Jochems, {Angela C. C.} and Maniega, {Susana Mu{\~n}oz} and Una Clancy and Carmen Arteaga and Garcia, {Daniela Jaime} and Chappell, {Francesca M.} and Will Hewins and Rachel Locherty and Backhouse, {Ellen V.} and Gayle Barclay and Charlotte Jardine and Donna McIntyre and Iona Gerrish and Agniete Kampaite and Eleni Sakka and Hern{\'a}ndez, {Maria Vald{\'e}s} and Stewart Wiseman and Bastin, {Mark E.} and Stringer, {Michael S.} and Thrippleton, {Michael J.} and Doubal, {Fergus N.} and Wardlaw, {Joanna M.}",

note = "Funding Information: This research was funded by the UK Dementia Research Institute, which receives its funding from DRI Ltd. funded by the UK Medical Research Council, Alzheimer{\textquoteright}s Society, and Alzheimer{\textquoteright}s Research UK; the Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease (16 CVD 05); Stroke Association Small Vessel Disease-Spotlight on Symptoms (SAPG 19n100068); British Heart Foundation Edinburgh Centre for Research Excellence (RE/18/5/34216); the Row Fogo Charitable Trust Centre for Research into Aging and the Brain. A.C.C.J. was funded by the Alzheimer{\textquoteright}s Society (ref 486 [AS-CP-18b-001]), University of Edinburgh College of Medicine and Veterinary Medicine, and the UK Dementia Research Institute, which receives funding from UK DRI Ltd. as described above. S.M.M. was funded by the Biotechnology and Biological Sciences Research Council, and the Economic and Social Research Council (BB/W008793/1). M.J.T. received funding from the National Health Service Lothian Research and Development Office. U.C. was funded by a Chief Scientist Office Clinical Academic Fellowship (CA/18) and is funded by the Scottish Clinical Excellence Research Development Scheme at the University of Edinburgh. D.J.G. is funded by the Wellcome Trust. C.A. receives funding from Mexican Council of Humanities Science and Technology, Anne Rowling Regenerative Neurology Clinic, and the Row Fogo Charitable Trust Centre into Aging and the Brain. The University 3T MRI Research scanner in the Royal Infirmary of Edinburgh is supported by the Scottish Funding Council through the Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) collaboration; the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), Edinburgh and Lothians Health Foundation (2012/17), Muir Maxwell Research Fund, Edinburgh Imaging, and the University of Edinburgh. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) license to any author-accepted article version arising. Publisher Copyright: {\textcopyright} 2024 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2024",

month = jan,

day = "31",

doi = "10.1161/JAHA.123.032259",

language = "English",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "American Heart Association Inc.",

}

Jochems, ACC , Maniega, SM , Clancy, U , Arteaga, C, Garcia, DJ, Chappell, FM, Hewins, W, Locherty, R, Backhouse, EV, Barclay, G, Jardine, C, McIntyre, D, Gerrish, I, Kampaite, A , Sakka, E , Hernández, MV, Wiseman, S, Bastin, ME , Stringer, MS , Thrippleton, MJ , Doubal, FN & Wardlaw, JM 2024, 'Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress', Journal of the American Heart Association. https://doi.org/10.1161/JAHA.123.032259

Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress. / Jochems, Angela C. C.; Maniega, Susana Muñoz ; Clancy, Una et al.
In: Journal of the American Heart Association, 31.01.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

AU - Jochems, Angela C. C.

AU - Maniega, Susana Muñoz

AU - Clancy, Una

AU - Arteaga, Carmen

AU - Garcia, Daniela Jaime

AU - Chappell, Francesca M.

AU - Hewins, Will

AU - Locherty, Rachel

AU - Backhouse, Ellen V.

AU - Barclay, Gayle

AU - Jardine, Charlotte

AU - McIntyre, Donna

AU - Gerrish, Iona

AU - Kampaite, Agniete

AU - Sakka, Eleni

AU - Hernández, Maria Valdés

AU - Wiseman, Stewart

AU - Bastin, Mark E.

AU - Stringer, Michael S.

AU - Thrippleton, Michael J.

AU - Doubal, Fergus N.

AU - Wardlaw, Joanna M.

N1 - Funding Information: This research was funded by the UK Dementia Research Institute, which receives its funding from DRI Ltd. funded by the UK Medical Research Council, Alzheimer’s Society, and Alzheimer’s Research UK; the Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease (16 CVD 05); Stroke Association Small Vessel Disease-Spotlight on Symptoms (SAPG 19n100068); British Heart Foundation Edinburgh Centre for Research Excellence (RE/18/5/34216); the Row Fogo Charitable Trust Centre for Research into Aging and the Brain. A.C.C.J. was funded by the Alzheimer’s Society (ref 486 [AS-CP-18b-001]), University of Edinburgh College of Medicine and Veterinary Medicine, and the UK Dementia Research Institute, which receives funding from UK DRI Ltd. as described above. S.M.M. was funded by the Biotechnology and Biological Sciences Research Council, and the Economic and Social Research Council (BB/W008793/1). M.J.T. received funding from the National Health Service Lothian Research and Development Office. U.C. was funded by a Chief Scientist Office Clinical Academic Fellowship (CA/18) and is funded by the Scottish Clinical Excellence Research Development Scheme at the University of Edinburgh. D.J.G. is funded by the Wellcome Trust. C.A. receives funding from Mexican Council of Humanities Science and Technology, Anne Rowling Regenerative Neurology Clinic, and the Row Fogo Charitable Trust Centre into Aging and the Brain. The University 3T MRI Research scanner in the Royal Infirmary of Edinburgh is supported by the Scottish Funding Council through the Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) collaboration; the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), Edinburgh and Lothians Health Foundation (2012/17), Muir Maxwell Research Fund, Edinburgh Imaging, and the University of Edinburgh. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) license to any author-accepted article version arising. Publisher Copyright: © 2024 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

PY - 2024/1/31

Y1 - 2024/1/31

UR - https://doi.org/10.1161/JAHA.123.032259

U2 - 10.1161/JAHA.123.032259

DO - 10.1161/JAHA.123.032259

M3 - Article

SN - 2047-9980

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

ER -

Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

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