MAGNETIC-RESONANCE RELAXATION-TIME MAPPING IN MULTIPLE-SCLEROSIS - NORMAL APPEARING WHITE-MATTER AND THE INVISIBLE LESION LOAD

S BARBOSA, LD BLUMHARDT, N ROBERTS, T LOCK, RHT EDWARDS

Research output: Contribution to journalArticlepeer-review

Abstract

Prolonged T-1 and/or T-2 relaxation times (RT) in the normal appearing white matter (NAWM) of patients with multiple sclerosis (MS) have been attributed either to a diffuse abnormality, or to ''small lesions'' undetected by visual inspection of conventional MR images. In a comparison of brain slices from five MS patients and five healthy control subjects, we have confirmed that the average T-1 and T-2 RTs obtained from NAWM in patients with MS are significantly prolonged (p

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalMagnetic Resonance Imaging
Volume12
Issue number1
Publication statusPublished - 1994

Keywords

  • MRI
  • MULTIPLE SCLEROSIS
  • NORMAL APPEARING WHITE MATTER
  • T-1 AND T-2 RELAXATION TIME
  • PIXEL MAPPING

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