Magnetoencephalogram background activity analysis in Alzheimer's disease patients using auto mutual information

Carlos Gomez, Roberto Hornero, Alberto Fernandez, Daniel Abasolo, Javier Escudero*, Miguel Lopez

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this study was to analyze the magnetoencephalogram (MEG) background activity in patients,with Alzheimer's disease (AD) using the auto mutual information (AMI). Applied to time series, AMI provides a measure of future points predictability from past points. Five minutes of recording were acquired with a 148-channel wholehead magnetometer (AIIAGNES 2500 NVH, 413 Neuroimaging) in 12 patients with probable AD and 12 elderly control subjects. Artifact-free epochs of 20 seconds (3392 points, sample frequency of 169.6 Hz) were selected for our study. Our results showed that the absolute values of the averaged decline rate of AIM were lower in AD patients than in control subjects for all channels. In addition, there were statistically significant differences (p <0.01, Student's t-test) in most channels. These preliminary results suggest that neuronal dysfunction in AD is associated with differences in the dynamical processes underlying the MEG recording.

Original languageEnglish
Title of host publication2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-15
Place of PublicationNEW YORK
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages312-315
Number of pages4
ISBN (Print)978-1-4244-0032-4
Publication statusPublished - 2006
Event28th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society - New York, United Kingdom
Duration: 30 Aug 20063 Sep 2006

Conference

Conference28th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Country/TerritoryUnited Kingdom
Period30/08/063/09/06

Keywords

  • APPROXIMATE ENTROPY
  • EEG
  • COMPLEXITY

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