Male breast neoplasia in association with selective serotonin re-uptake inhibitor therapy: a report of three cases

W A Wallace, M Balsitis, B J Harrison

Research output: Contribution to journalArticlepeer-review

Abstract

Male breast cancer is a rare condition with very poorly understood risk factors. We report three cases of men with malignant and pre-malignant breast disease who had all been prescribed selective serotonin re-uptake inhibitors (SSRIs) for depression. Concerns about an association between this group of drugs and breast cancer in women have been previously raised and experimental evidence has suggested that these drugs could influence regulation of cellular proliferation acting through internal cellular messengers. Risk factors for the development of breast cancer are likely to be multifactorial, possibly more so in women given the complex physiological changes that occur in the female breast. Whilst the cases we report are anecdotal and other risk factors may be present, we suggest that assessment of any possible contribution that SSRI therapy may make to the development of breast neoplasia may be more easily assessed in a male population.

Original languageEnglish
Pages (from-to)429-31
Number of pages3
JournalEJSO - European Journal of Surgical Oncology
Volume27
Issue number4
DOIs
Publication statusPublished - Jun 2001

Keywords

  • Aged
  • Antidepressive Agents, Second-Generation
  • Breast Neoplasms, Male
  • Fluoxetine
  • Humans
  • Male
  • Middle Aged
  • Paroxetine
  • Risk Factors
  • Serotonin Uptake Inhibitors

Fingerprint Dive into the research topics of 'Male breast neoplasia in association with selective serotonin re-uptake inhibitor therapy: a report of three cases'. Together they form a unique fingerprint.

Cite this