Male contraception

Jing Chao, Stephanie T Page, Richard Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

Clear evidence shows that many men and women would welcome new male methods of contraception, but none have become available. The hormonal approach is based on suppression of gonadotropins and thus of testicular function and spermatogenesis, and has been investigated for several decades. This approach can achieve sufficient suppression of spermatogenesis for effective contraception in most men, but not all; the basis for these men responding insufficiently is unclear. Alternatively, the non-hormonal approach is based on identifying specific processes in sperm development, maturation and function. A range of targets has been identified in animal models, and targeted effectively. This approach, however, remains in the pre-clinical domain at present. There are, therefore, grounds for considering that safe, effective and reversible methods of contraception for men can be developed.

Original languageEnglish
Pages (from-to)845-57
Number of pages13
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Volume28
Issue number6
DOIs
Publication statusPublished - Aug 2014

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