Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb

K L Hammond, I M Hanson, A G Brown, L A Lettice, R E Hill

Research output: Contribution to journalArticlepeer-review

Abstract

We have isolated mammalian homologues of the Drosophila dachshund gene. Two domains of high conservation, one of which contains an alpha-helical, coiled-coil motif, show similarity to the Ski family of genes. We therefore propose that Dachshund belongs to a superfamily including these genes. Mouse Dachshund (Dach) is expressed in the eye and limb, structures affected by the Drosophila loss-of-function mutant, and rib primordia, CNS and genital eminence. Pax6 and Dach show overlapping but non-identical expression patterns. Dach expression is unaffected in smalleye mouse brain, indicating that Pax6 is not directly activating Dach. In Drosophila eye development dachshund is a component of an interacting network of proteins. Genes homologous to many of these exist in mammals; Dach joins this expanding group.
Original languageEnglish
Pages (from-to)121-31
Number of pages11
JournalMechanisms of Development
Volume74
Issue number1-2
Publication statusPublished - 1998

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