Mammalian interspecies substitution of immune modulatory alleles by genome editing

Simon Lillico, Christopher Proudfoot, Timothy King, Wenfang Tan, Lei Zhang, Rachel Mardjuki, David E. Paschon, Edward J Rebar, Fyodor D Urnov, Alan J Mileham, David G McLaren, Christopher Whitelaw

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one generation opens unprecedented opportunities for agriculture and basic research.
Original languageEnglish
Article number21645
JournalScientific Reports
Volume6
Early online date22 Feb 2016
DOIs
Publication statusE-pub ahead of print - 22 Feb 2016

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