Projects per year
Abstract
We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one generation opens unprecedented opportunities for agriculture and basic research.
Original language | English |
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Article number | 21645 |
Journal | Scientific Reports |
Volume | 6 |
Early online date | 22 Feb 2016 |
DOIs | |
Publication status | E-pub ahead of print - 22 Feb 2016 |
Fingerprint
Dive into the research topics of 'Mammalian interspecies substitution of immune modulatory alleles by genome editing'. Together they form a unique fingerprint.Projects
- 4 Finished
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Genus Master Agreement: Genus Chair Funds
Non-EU industry, commerce and public corporations
1/01/13 → 31/12/21
Project: Research
Profiles
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Simon Lillico
- Royal (Dick) School of Veterinary Studies - Core Scientist (Research Fellow)
- Edinburgh Imaging
Person: Academic: Research Active
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Bruce Whitelaw
- Royal (Dick) School of Veterinary Studies - Director of The Roslin Institute
- Edinburgh Imaging
- Global Academy of Agriculture and Food Systems
Person: Academic: Research Active