Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial

Heather Powell; Vanessa E Murphy; D Robin Taylor; Michael J Hensley; Kirsten McCaffery; Warwick Giles; Vicki L Clifton; Peter G Gibson

doi:10.1016/S0140-6736(11)60971-9

Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial

Heather Powell, Vanessa E Murphy, D Robin Taylor, Michael J Hensley, Kirsten McCaffery, Warwick Giles, Vicki L Clifton, Peter G Gibson

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Asthma exacerbations during pregnancy are common and can be associated with substantial maternal and fetal morbidity. Treatment decisions based on sputum eosinophil counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal. We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations.

Original language	English
Pages (from-to)	983-90
Number of pages	8
Journal	The Lancet
Volume	378
Issue number	9795
DOIs	https://doi.org/10.1016/S0140-6736(11)60971-9
Publication status	Published - 10 Sept 2011

Keywords / Materials (for Non-textual outputs)

Administration, Inhalation
Administration, Oral
Adrenergic beta-2 Receptor Agonists
Adult
Asthma
Breath Tests
Bronchodilator Agents
Budesonide
Double-Blind Method
Ethanolamines
Female
Forced Expiratory Volume
Glucocorticoids
Humans
Nitric Oxide
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Vital Capacity

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10.1016/S0140-6736(11)60971-9

Cite this

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title = "Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial",

abstract = "Asthma exacerbations during pregnancy are common and can be associated with substantial maternal and fetal morbidity. Treatment decisions based on sputum eosinophil counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal. We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations.",

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T1 - Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide

T2 - a double-blind, randomised controlled trial

AU - Powell, Heather

AU - Murphy, Vanessa E

AU - Taylor, D Robin

AU - Hensley, Michael J

AU - McCaffery, Kirsten

AU - Giles, Warwick

AU - Clifton, Vicki L

AU - Gibson, Peter G

PY - 2011/9/10

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N2 - Asthma exacerbations during pregnancy are common and can be associated with substantial maternal and fetal morbidity. Treatment decisions based on sputum eosinophil counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal. We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations.

AB - Asthma exacerbations during pregnancy are common and can be associated with substantial maternal and fetal morbidity. Treatment decisions based on sputum eosinophil counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal. We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations.

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KW - Adrenergic beta-2 Receptor Agonists

KW - Adult

KW - Asthma

KW - Breath Tests

KW - Bronchodilator Agents

KW - Budesonide

KW - Double-Blind Method

KW - Ethanolamines

KW - Female

KW - Forced Expiratory Volume

KW - Glucocorticoids

KW - Humans

KW - Nitric Oxide

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Outcome

KW - Vital Capacity

U2 - 10.1016/S0140-6736(11)60971-9

DO - 10.1016/S0140-6736(11)60971-9

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SN - 0140-6736

VL - 378

SP - 983

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JO - The Lancet

JF - The Lancet

IS - 9795

ER -

Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial

Abstract

Keywords / Materials (for Non-textual outputs)

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