Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial

Heather Powell, Vanessa E Murphy, D Robin Taylor, Michael J Hensley, Kirsten McCaffery, Warwick Giles, Vicki L Clifton, Peter G Gibson

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma exacerbations during pregnancy are common and can be associated with substantial maternal and fetal morbidity. Treatment decisions based on sputum eosinophil counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal. We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations.
Original languageEnglish
Pages (from-to)983-90
Number of pages8
JournalThe Lancet
Volume378
Issue number9795
DOIs
Publication statusPublished - 10 Sep 2011

Keywords

  • Administration, Inhalation
  • Administration, Oral
  • Adrenergic beta-2 Receptor Agonists
  • Adult
  • Asthma
  • Breath Tests
  • Bronchodilator Agents
  • Budesonide
  • Double-Blind Method
  • Ethanolamines
  • Female
  • Forced Expiratory Volume
  • Glucocorticoids
  • Humans
  • Nitric Oxide
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Outcome
  • Vital Capacity

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