Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology

International Society of Geriatric Oncology, Hans Wildiers, Ian Kunkler, Laura Biganzoli, Jacques Fracheboud, George Vlastos, Chantal Bernard-Marty, Arti Hurria, Martine Extermann, Véronique Girre, Etienne Brain, Riccardo A Audisio, Harry Bartelink, Mary Barton, Sharon H Giordano, Hyman Muss, Matti Aapro

Research output: Contribution to journalArticlepeer-review


Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in women worldwide. Elderly individuals make up a large part of the breast cancer population, and there are important specific considerations for this population. The International Society of Geriatric Oncology created a task force to assess the available evidence on breast cancer in elderly individuals, and to provide evidence-based recommendations for the diagnosis and treatment of breast cancer in such individuals. A review of the published work was done with the results of a search on Medline for English-language articles published between 1990 and 2007 and of abstracts from key international conferences. Recommendations are given on the topics of screening, surgery, radiotherapy, (neo)adjuvant hormone treatment and chemotherapy, and metastatic disease. Since large randomised trials in elderly patients with breast cancer are scarce, there is little level I evidence for the treatment of such patients. The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults.
Original languageEnglish
Pages (from-to)1101-15
Number of pages15
JournalThe Lancet Oncology
Issue number12
Publication statusPublished - Dec 2007


  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Axilla
  • Breast Neoplasms
  • Chemotherapy, Adjuvant
  • Evidence-Based Medicine
  • Female
  • Health Services for the Aged
  • Humans
  • Lymph Node Excision
  • Mass Screening
  • Mastectomy
  • Mastectomy, Segmental
  • Medical Oncology
  • Neoplasm Metastasis
  • Radiotherapy, Adjuvant
  • Societies, Medical
  • Treatment Outcome


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