Management of women who test positive for high-risk types of human papillomavirus: the HART study

J Cuzick; A Szarewski; H Cubie; G Hulman; H Kitchener; D Luesley; E McGoogan; U Menon; G Terry; R Edwards; C Brooks; M Desai; C Gie; L Ho; I Jacobs; C Pickles; P Sasieni

doi:10.1016/S0140-6736(03)14955-0

Management of women who test positive for high-risk types of human papillomavirus: the HART study

J Cuzick, A Szarewski, H Cubie, G Hulman, H Kitchener, D Luesley, E McGoogan, U Menon, G Terry, R Edwards, C Brooks, M Desai, C Gie, L Ho, I Jacobs, C Pickles, P Sasieni

Research output: Contribution to journal › Article › peer-review

Abstract

Certain types of human papillomavirus (HPV) are the primary cause of almost all cervical cancers. HPV testing of cervical smears is more sensitive but less specific than cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+). HPV testing as a primary screening approach requires efficient management of HPV-positive women with negative or borderline cytology. We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women.

Original language	English
Pages (from-to)	1871-6
Number of pages	6
Journal	The Lancet
Volume	362
Issue number	9399
DOIs	https://doi.org/10.1016/S0140-6736(03)14955-0
Publication status	Published - 6 Dec 2003

Keywords / Materials (for Non-textual outputs)

Adult
Age Factors
Cervical Intraepithelial Neoplasia
Colposcopy
DNA Probes, HPV
DNA, Viral
Female
Humans
Mass Screening
Middle Aged
Papillomaviridae
Sensitivity and Specificity
Uterine Cervical Neoplasms
Vaginal Smears

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Cuzick, J., Szarewski, A., Cubie, H., Hulman, G., Kitchener, H., Luesley, D., McGoogan, E., Menon, U., Terry, G., Edwards, R., Brooks, C., Desai, M., Gie, C., Ho, L., Jacobs, I., Pickles, C., & Sasieni, P. (2003). Management of women who test positive for high-risk types of human papillomavirus: the HART study. The Lancet, 362(9399), 1871-6. https://doi.org/10.1016/S0140-6736(03)14955-0

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title = "Management of women who test positive for high-risk types of human papillomavirus: the HART study",

abstract = "Certain types of human papillomavirus (HPV) are the primary cause of almost all cervical cancers. HPV testing of cervical smears is more sensitive but less specific than cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+). HPV testing as a primary screening approach requires efficient management of HPV-positive women with negative or borderline cytology. We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women.",

keywords = "Adult, Age Factors, Cervical Intraepithelial Neoplasia, Colposcopy, DNA Probes, HPV, DNA, Viral, Female, Humans, Mass Screening, Middle Aged, Papillomaviridae, Sensitivity and Specificity, Uterine Cervical Neoplasms, Vaginal Smears",

author = "J Cuzick and A Szarewski and H Cubie and G Hulman and H Kitchener and D Luesley and E McGoogan and U Menon and G Terry and R Edwards and C Brooks and M Desai and C Gie and L Ho and I Jacobs and C Pickles and P Sasieni",

year = "2003",

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doi = "10.1016/S0140-6736(03)14955-0",

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Cuzick, J, Szarewski, A, Cubie, H, Hulman, G, Kitchener, H, Luesley, D, McGoogan, E, Menon, U, Terry, G, Edwards, R, Brooks, C, Desai, M, Gie, C, Ho, L, Jacobs, I, Pickles, C & Sasieni, P 2003, 'Management of women who test positive for high-risk types of human papillomavirus: the HART study', The Lancet, vol. 362, no. 9399, pp. 1871-6. https://doi.org/10.1016/S0140-6736(03)14955-0

TY - JOUR

T1 - Management of women who test positive for high-risk types of human papillomavirus

T2 - the HART study

AU - Cuzick, J

AU - Szarewski, A

AU - Cubie, H

AU - Hulman, G

AU - Kitchener, H

AU - Luesley, D

AU - McGoogan, E

AU - Menon, U

AU - Terry, G

AU - Edwards, R

AU - Brooks, C

AU - Desai, M

AU - Gie, C

AU - Ho, L

AU - Jacobs, I

AU - Pickles, C

AU - Sasieni, P

PY - 2003/12/6

Y1 - 2003/12/6

N2 - Certain types of human papillomavirus (HPV) are the primary cause of almost all cervical cancers. HPV testing of cervical smears is more sensitive but less specific than cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+). HPV testing as a primary screening approach requires efficient management of HPV-positive women with negative or borderline cytology. We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women.

AB - Certain types of human papillomavirus (HPV) are the primary cause of almost all cervical cancers. HPV testing of cervical smears is more sensitive but less specific than cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+). HPV testing as a primary screening approach requires efficient management of HPV-positive women with negative or borderline cytology. We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women.

KW - Adult

KW - Age Factors

KW - Cervical Intraepithelial Neoplasia

KW - Colposcopy

KW - DNA Probes, HPV

KW - DNA, Viral

KW - Female

KW - Humans

KW - Mass Screening

KW - Middle Aged

KW - Papillomaviridae

KW - Sensitivity and Specificity

KW - Uterine Cervical Neoplasms

KW - Vaginal Smears

U2 - 10.1016/S0140-6736(03)14955-0

DO - 10.1016/S0140-6736(03)14955-0

M3 - Article

C2 - 14667741

SN - 0140-6736

VL - 362

SP - 1871

EP - 1876

JO - The Lancet

JF - The Lancet

IS - 9399

ER -

Management of women who test positive for high-risk types of human papillomavirus: the HART study

Abstract

Keywords / Materials (for Non-textual outputs)

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