Management of women who test positive for high-risk types of human papillomavirus: the HART study

J Cuzick, A Szarewski, H Cubie, G Hulman, H Kitchener, D Luesley, E McGoogan, U Menon, G Terry, R Edwards, C Brooks, M Desai, C Gie, L Ho, I Jacobs, C Pickles, P Sasieni

Research output: Contribution to journalArticlepeer-review

Abstract

Certain types of human papillomavirus (HPV) are the primary cause of almost all cervical cancers. HPV testing of cervical smears is more sensitive but less specific than cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+). HPV testing as a primary screening approach requires efficient management of HPV-positive women with negative or borderline cytology. We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women.
Original languageEnglish
Pages (from-to)1871-6
Number of pages6
JournalThe Lancet
Volume362
Issue number9399
DOIs
Publication statusPublished - 6 Dec 2003

Keywords

  • Adult
  • Age Factors
  • Cervical Intraepithelial Neoplasia
  • Colposcopy
  • DNA Probes, HPV
  • DNA, Viral
  • Female
  • Humans
  • Mass Screening
  • Middle Aged
  • Papillomaviridae
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms
  • Vaginal Smears

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