Manganese-catalyzed Hydrofunctionalization of Alkenes

Stephen Thomas, Jonathan Carney, Leonie Campbell, Barry Dillon

Research output: Contribution to journalArticlepeer-review

Abstract

The manganese-catalyzed hydrosilylation andhydroboration of alkenes has been developed using a single Mn(II) pre-catalyst and reaction protocol. Both reactions proceed withexcellent control of regioselectivity in high yields across a variety of
sterically and electronically differentiated substrates (25 examples). Alkoxide activation, using NaOtBu, was key to pre-catalyst activation and reactivity. Catalysis was achieved across various functional groups and on gram-scale across both the developed methodologies with catalysts loadings as low as 0.5 mol%.
Original languageEnglish
JournalAngewandte Chemie International Edition
Early online date12 Jun 2018
DOIs
Publication statusE-pub ahead of print - 12 Jun 2018

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