Projects per year
Mathematical modeling has been instrumental in identifying common principles of cell polarity across diverse systems. These principles include positive feedback loops that are required to destabilize a spatially uniform state of the cell. Conserved small G-protein Cdc42 is a master regulator of eukaryotic cellular polarization. Here we discuss recent developments in studies of Cdc42 polarization in budding and fission yeasts and demonstrate that models describing symmetry-breaking polarization can be classified into six minimal classes based on the structure of positive feedback loops that activate and localize Cdc42. Due to their generic system-independent nature, these model classes are also likely to be relevant for the G-protein-based symmetry breaking systems of higher eukaryotes. We review experimental evidence pro et contra different theoretically plausible models and conclude that several parallel and non-mutually-exclusive mechanisms are likely involved in cellular polarization of yeasts. This potential redundancy needs to be taken into consideration when interpreting the results of recent cell-rewiring studies.
|Journal||Molecular Biology of the Cell|
|Publication status||Published - 1 Feb 2017|
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- 1 Finished
Dynamics and interaction of cell-polarity landmark proteins and the Cdc42 GTPase module: a systems approach
1/07/14 → 30/06/17
- School of Biological Sciences - Personal Chair in Computational Cell Biology
- Centre for Engineering Biology
Person: Academic: Research Active