Abstract / Description of output
Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings that over 90% of GWAS variants map outside of protein-coding DNA and instead are enriched in cell type- and stimulation-specific gene regulatory regions.
Original language | English |
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Article number | 47 |
Journal | BMC Biology |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4 May 2020 |
Keywords / Materials (for Non-textual outputs)
- CRISPR
- GWAS
- chromatin
- CHi-C
- HiChIP
- KLF4
- psoriasis