Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings that over 90% of GWAS variants map outside of protein-coding DNA and instead are enriched in cell type- and stimulation-specific gene regulatory regions.
Original languageEnglish
Article number47
JournalBMC Biology
Volume18
Issue number1
DOIs
Publication statusPublished - 4 May 2020

Keywords / Materials (for Non-textual outputs)

  • CRISPR
  • GWAS
  • chromatin
  • CHi-C
  • HiChIP
  • KLF4
  • psoriasis

Fingerprint

Dive into the research topics of 'Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31'. Together they form a unique fingerprint.

Cite this