Mapping Endocrine Networks by Stable Isotope Tracing

Ruth Andrew*, Roland H Stimson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Hormones regulate metabolic homeostasis through interlinked dynamic networks of proteins and small molecular weight metabolites and state-of-the-art chemical technologies have been developed to decipher these complex pathways. Stable-isotope tracers have largely replaced radiotracers to measure flux in humans, building on advances in nuclear magnetic resonance spectroscopy and mass spectrometry. These technologies are now being applied to localise molecules within tissues. Radiotracers are still highly valuable both preclinically and in 3D imaging by positron emission tomography. The coming of age of vibrational spectroscopy in conjunction with stable-isotope tracing offers detailed cellular insights to map complex biological processes. Together with computational modelling, these approaches are poised to coalesce into multi-modal platforms to provide hitherto inaccessible dynamic and spatial insights into endocrine signalling.
Original languageEnglish
JournalCurrent Opinion in Endocrine and Metabolic Research
Early online date19 Jul 2022
Publication statusE-pub ahead of print - 19 Jul 2022

Keywords / Materials (for Non-textual outputs)

  • steroid
  • stable-isotope
  • flux
  • mass spectrometry
  • magnetic resonance
  • vibrational spectroscopy
  • positron emission tomography


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