Mapping in the region of Danforth's short tail and the localization of tail length modifiers

J B Alfred; Kellie A Rance; B A Taylor; Sandra  J. Phillips; Catherine Abbott; Ian Jackson

doi:10.1101/gr.7.2.108

Mapping in the region of Danforth's short tail and the localization of tail length modifiers

J B Alfred, Kellie A Rance, B A Taylor, Sandra J. Phillips, Catherine Abbott, Ian Jackson

Research output: Contribution to journal › Article › peer-review

Abstract

We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.

Original language	English
Pages (from-to)	108-17
Number of pages	10
Journal	Genome Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1101/gr.7.2.108
Publication status	Published - Feb 1997

Keywords / Materials (for Non-textual outputs)

Alleles
Animals
Chromosome Mapping
Chromosomes, Human, Pair 1/genetics
Chromosomes, Human, Pair 10/genetics
Chromosomes, Human, Pair 18/genetics
Chromosomes, Human, Pair 9/genetics
Female
Genetic Linkage
Genetic Markers
Genome
Haplotypes
Humans
Male
Mice
Mice, Inbred CBA
Mice, Mutant Strains/genetics
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
Tail/abnormalities

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http://genome.cshlp.org/content/7/2/108.long

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title = "Mapping in the region of Danforth's short tail and the localization of tail length modifiers",

abstract = "We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.",

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author = "Alfred, {J B} and Rance, {Kellie A} and Taylor, {B A} and Phillips, {Sandra J.} and Catherine Abbott and Ian Jackson",

year = "1997",

month = feb,

doi = "10.1101/gr.7.2.108",

language = "English",

volume = "7",

pages = "108--17",

journal = "Genome Research",

issn = "1088-9051",

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T1 - Mapping in the region of Danforth's short tail and the localization of tail length modifiers

AU - Alfred, J B

AU - Rance, Kellie A

AU - Taylor, B A

AU - Phillips, Sandra J.

AU - Abbott, Catherine

AU - Jackson, Ian

PY - 1997/2

Y1 - 1997/2

N2 - We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.

AB - We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.

KW - Alleles

KW - Animals

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 1/genetics

KW - Chromosomes, Human, Pair 10/genetics

KW - Chromosomes, Human, Pair 18/genetics

KW - Chromosomes, Human, Pair 9/genetics

KW - Female

KW - Genetic Linkage

KW - Genetic Markers

KW - Genome

KW - Haplotypes

KW - Humans

KW - Male

KW - Mice

KW - Mice, Inbred CBA

KW - Mice, Mutant Strains/genetics

KW - Polymorphism, Genetic

KW - Repetitive Sequences, Nucleic Acid

KW - Sequence Analysis, DNA

KW - Tail/abnormalities

U2 - 10.1101/gr.7.2.108

DO - 10.1101/gr.7.2.108

M3 - Article

C2 - 9049629

SN - 1088-9051

VL - 7

SP - 108

EP - 117

JO - Genome Research

JF - Genome Research

IS - 2

ER -

Mapping in the region of Danforth's short tail and the localization of tail length modifiers

Abstract

Keywords / Materials (for Non-textual outputs)

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