Mapping in the region of Danforth's short tail and the localization of tail length modifiers

J B Alfred, Kellie A Rance, B A Taylor, Sandra J. Phillips, Catherine Abbott, Ian Jackson

Research output: Contribution to journalArticlepeer-review

Abstract

We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.
Original languageEnglish
Pages (from-to)108-17
Number of pages10
JournalGenome Research
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 1997

Keywords

  • Alleles
  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1/genetics
  • Chromosomes, Human, Pair 10/genetics
  • Chromosomes, Human, Pair 18/genetics
  • Chromosomes, Human, Pair 9/genetics
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genome
  • Haplotypes
  • Humans
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Mutant Strains/genetics
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA
  • Tail/abnormalities

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