Mapping Mendelian traits in asexual progeny using changes in marker allele frequency

Sayanthan Logeswaran*, Nick H. Barton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Linkage between markers and genes that affect a phenotype of interest may be determined by examining differences in marker allele frequency in the extreme progeny of a cross between two inbred lines. This strategy is usually employed when pooling is used to reduce genotyping costs. When the cross progeny are asexual, the extreme progeny may be selected by multiple generations of asexual reproduction and selection. We analyse this method of measuring phenotype in asexual progeny and examine the changes in marker allele frequency due to selection over many generations. Stochasticity in marker frequency in the selected population arises due to the finite initial population size. We derive the distribution of marker frequency as a result of selection at a single major locus, and show that in order to avoid spurious changes in marker allele frequency in the selected population, the initial population size should be in the low to mid hundreds.

Original languageEnglish
Pages (from-to)221-232
Number of pages12
JournalGenetics Research
Volume93
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords / Materials (for Non-textual outputs)

  • LINES
  • DROSOPHILA
  • CROSSES
  • MALARIA PARASITES
  • LINKAGE
  • IDENTIFICATION
  • SEGREGANT ANALYSIS
  • RESISTANCE
  • LOCI
  • SELECTION

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