Mapping of genes involved in susceptibility to E. coli and helminth infection in pigs

M.J. Jacobsen, P. Nejsum, D. Joller, H.U. Bertschinger, P. Python, I. Edfors, S. Cirera, A.L. Archibald, C. Churcher, G. Esteso, E. Burgi, P. Karlskov-Mortensen, L. Anderson, P. Voegeli, A. Roepstorff, H.H.H. Goering, T.J.C. Anderson, S.M. Thamsborg, M. Fredholm, C.B. Jorgensen

Research output: Contribution to conferenceAbstract


E.coli and helminth infections cause significant health and welfare problems and compromise the sustainability of pig production systems. The enterotoxigenic E. coli O149, F4ac alone is responsible for more than 30% of the E. coli diarrhea cases in piglets. Studies have shown that susceptibility both to specific E. coli and helminth types are under genetic control. Resource families, where these susceptibility traits are segregating, have been constructed and our data demonstrate that genetic components are involved in resistance to E. coli F4ab/ac, Ascaris and Trichuris infections. Genome scans have been performed in order to locate genomic regions controlling susceptibility in the pig. For Ascaris and Thichuris infections a total of 195 pigs from 19 full-sib litters have been genotyped for 4890 SNPs and the genotypes are ready for linkage analysis. In relation to E. coli F4ac-susceptibility we have narrow down the candidate region to less than 3 Mb around the mucin 4 gene in the q41-region on pig chromosome 13. Haplotyping data of the mucin 4 region using more than 200 SNPs shows a large shared haplotype block on the chromosomes carrying
the susceptible allele. These results were obtained, in part, through the EC-funded FP6 project ‘SABRE’.
Original languageUndefined/Unknown
Number of pages1
Publication statusPublished - 2009
Event60th Annual Meeting of the European Association for Animal Production - Barcelona, Spain
Duration: 24 Aug 200927 Aug 2009


Conference60th Annual Meeting of the European Association for Animal Production

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