Mapping of quantitative trait loci on porcine chromosome 4

G A Walling; A L Archibald; J A Cattermole; A C Downing; H A Finlayson; D Nicholson; P M Visscher; C A Walker; C S Haley

Mapping of quantitative trait loci on porcine chromosome 4

G A Walling, A L Archibald, J A Cattermole, A C Downing, H A Finlayson, D Nicholson, P M Visscher, C A Walker, C S Haley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

A F2 population derived from a cross between European Large White and Chinese Meishan pigs was established in order to study the genetic basis of breed differences for growth and fat traits. Chromosome 4 was chosen for initial study as previous work had revealed quantitative trait loci (QTLs) on this chromosome affected growth and fat traits in a Wild Boar x Large White cross. Individuals in the F2 population were typed for nine markers spanning a region of approximately 124 CM. We found evidence for QTLs affecting growth between weaning and the end of test (additive effect: 43.4 g/day) and fat depth measured in the mid-back position (additive effect: 1.82 mm). There was no evidence of interactions between the QTLs and sex, grandparents or F1 sires, suggesting that the detected QTLs were fixed for alternative alleles in the Meishan and Large White breeds. Comparison of locations suggests that these QTLs could be the same as those found in the Wild Boar x Large White cross.

Original language	English
Pages (from-to)	415-24
Number of pages	10
Journal	Animal Genetics
Volume	29
Issue number	6
Publication status	Published - Dec 1998

Keywords / Materials (for Non-textual outputs)

Animals
Chromosome Mapping
Chromosomes
Female
Genotype
Male
Phenotype
Quantitative Trait, Heritable
Swine

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@article{277b231f9ee14af6b13176675f6faa0e,

title = "Mapping of quantitative trait loci on porcine chromosome 4",

abstract = "A F2 population derived from a cross between European Large White and Chinese Meishan pigs was established in order to study the genetic basis of breed differences for growth and fat traits. Chromosome 4 was chosen for initial study as previous work had revealed quantitative trait loci (QTLs) on this chromosome affected growth and fat traits in a Wild Boar x Large White cross. Individuals in the F2 population were typed for nine markers spanning a region of approximately 124 CM. We found evidence for QTLs affecting growth between weaning and the end of test (additive effect: 43.4 g/day) and fat depth measured in the mid-back position (additive effect: 1.82 mm). There was no evidence of interactions between the QTLs and sex, grandparents or F1 sires, suggesting that the detected QTLs were fixed for alternative alleles in the Meishan and Large White breeds. Comparison of locations suggests that these QTLs could be the same as those found in the Wild Boar x Large White cross.",

keywords = "Animals, Chromosome Mapping, Chromosomes, Female, Genotype, Male, Phenotype, Quantitative Trait, Heritable, Swine",

author = "Walling, {G A} and Archibald, {A L} and Cattermole, {J A} and Downing, {A C} and Finlayson, {H A} and D Nicholson and Visscher, {P M} and Walker, {C A} and Haley, {C S}",

year = "1998",

month = dec,

language = "English",

volume = "29",

pages = "415--24",

journal = "Animal Genetics",

issn = "0268-9146",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Mapping of quantitative trait loci on porcine chromosome 4

AU - Walling, G A

AU - Archibald, A L

AU - Cattermole, J A

AU - Downing, A C

AU - Finlayson, H A

AU - Nicholson, D

AU - Visscher, P M

AU - Walker, C A

AU - Haley, C S

PY - 1998/12

Y1 - 1998/12

N2 - A F2 population derived from a cross between European Large White and Chinese Meishan pigs was established in order to study the genetic basis of breed differences for growth and fat traits. Chromosome 4 was chosen for initial study as previous work had revealed quantitative trait loci (QTLs) on this chromosome affected growth and fat traits in a Wild Boar x Large White cross. Individuals in the F2 population were typed for nine markers spanning a region of approximately 124 CM. We found evidence for QTLs affecting growth between weaning and the end of test (additive effect: 43.4 g/day) and fat depth measured in the mid-back position (additive effect: 1.82 mm). There was no evidence of interactions between the QTLs and sex, grandparents or F1 sires, suggesting that the detected QTLs were fixed for alternative alleles in the Meishan and Large White breeds. Comparison of locations suggests that these QTLs could be the same as those found in the Wild Boar x Large White cross.

AB - A F2 population derived from a cross between European Large White and Chinese Meishan pigs was established in order to study the genetic basis of breed differences for growth and fat traits. Chromosome 4 was chosen for initial study as previous work had revealed quantitative trait loci (QTLs) on this chromosome affected growth and fat traits in a Wild Boar x Large White cross. Individuals in the F2 population were typed for nine markers spanning a region of approximately 124 CM. We found evidence for QTLs affecting growth between weaning and the end of test (additive effect: 43.4 g/day) and fat depth measured in the mid-back position (additive effect: 1.82 mm). There was no evidence of interactions between the QTLs and sex, grandparents or F1 sires, suggesting that the detected QTLs were fixed for alternative alleles in the Meishan and Large White breeds. Comparison of locations suggests that these QTLs could be the same as those found in the Wild Boar x Large White cross.

KW - Animals

KW - Chromosome Mapping

KW - Chromosomes

KW - Female

KW - Genotype

KW - Male

KW - Phenotype

KW - Quantitative Trait, Heritable

KW - Swine

M3 - Article

C2 - 9883502

SN - 0268-9146

VL - 29

SP - 415

EP - 424

JO - Animal Genetics

JF - Animal Genetics

IS - 6

ER -

Mapping of quantitative trait loci on porcine chromosome 4

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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