Mapping of the human homologs of the murine paired-box-containing genes

A J Pilz, S Povey, P Gruss, C M Abbott

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in paired-box-containing (Pax) genes have recently been found to be the primary lesions underlying human genetic disorders such as Waardenburg's Syndrome type 1 and mouse developmental mutants such as undulated (un), splotch (Sp), and small eye (Sey). In addition, PAX-6 is a strong candidate gene for aniridia in man. Eight independent Pax genes have been isolated in the mouse. All eight map to distinct regions of the mouse genome; they do not appear to be clustered in the same way as some groups of homeobox-containing genes. We have now mapped the human homologs of all eight of these genes; PAX genes are found on human Chromosomes (Chr) 1, 2, 7, 9, 10, 11, and 20.
Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalMammalian Genome
Volume4
Issue number2
Publication statusPublished - 1993

Keywords

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • Humans
  • Hybrid Cells
  • Mice
  • Molecular Sequence Data

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