Abstract / Description of output
Comparative mapping studies in human and mouse have shown that, to date, human Chromosome (Chr) 20 is completely syntenic with distal mouse Chr 2. The structural locus for S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) in human, AHCY, maps to 20 qter-->q13.1, and we report here that the homologous locus in the mouse, Ahcy, maps to distal mouse Chr 2 with gene order Pcna-Ahcy-Ada. Analysis of 123 progeny of an interspecific backcross between a laboratory stock, AN, and Mus spretus using a rat cDNA probe revealed the presence of at least two other Ahcy-related sequences segregating independently in the mouse genome. One, Ahcy-rs1, was mapped to Chr 8 in the BXH recombinant inbred strains, and the other, Ahcy-rs2, shows a pattern of inheritance consistent with X-linkage.
| Original language | English |
|---|---|
| Pages (from-to) | 633-6 |
| Number of pages | 4 |
| Journal | Mammalian Genome |
| Volume | 3 |
| Issue number | 11 |
| Publication status | Published - 1992 |
Keywords / Materials (for Non-textual outputs)
- Adenosine Deaminase
- Adenosylhomocysteinase
- Animals
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- DNA
- DNA Probes
- Female
- Genes
- Genetic Linkage
- Hydrolases
- Male
- Mice
- Mice, Inbred C3H
- X Chromosome