Projects per year
In many organisms, the circadian clock is composed of functionally coupled morning and evening oscillators. In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TOC1 (TIMING OF CAB EXPRESSION1) was proposed to activate a subset of morning-expressed oscillator genes. Here, we show that TOC1 does not function as an activator but as a general repressor of oscillator gene expression. Repression occurs through TOC1 rhythmic association to the promoters of the oscillator genes. Hormone-dependent induction of TOC1 and analysis of RNAi plants show that TOC1 prevents the activation of morning-expressed genes at night. Our study overturns the prevailing model of the Arabidopsis circadian clock showing that the morning and evening oscillator loops are connected through the repressing activity of TOC1.
|Number of pages||5|
|Early online date||8 Mar 2012|
|Publication status||Published - 6 Apr 2012|
- biological clocks
- Arabidopsis thaliana
- systems biology
- Circadian Rhythms
- Gene Regulatory Networks
- Transcription Factors
FingerprintDive into the research topics of 'Mapping the Core of the Arabidopsis Circadian Clock Defines the Network Structure of the Oscillator'. Together they form a unique fingerprint.
- 2 Finished
TiMet: Linking the clock to metabolism
1/03/10 → 28/02/15
SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
8/01/07 → 31/12/12