Marked seasonal variation in the wild mouse gut microbiota

Corinne F Maurice, Sarah Cl Knowles, Joshua Ladau, Katherine S Pollard, Andy Fenton, Amy B Pedersen, Peter J Turnbaugh

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have provided an unprecedented view of the microbial communities colonizing captive mice; yet the host and environmental factors that shape the rodent gut microbiota in their natural habitat remain largely unexplored. Here, we present results from a 2-year 16 S ribosomal RNA gene sequencing-based survey of wild wood mice (Apodemus sylvaticus) in two nearby woodlands. Similar to other mammals, wild mice were colonized by 10 bacterial phyla and dominated by the Firmicutes, Bacteroidetes and Proteobacteria. Within the Firmicutes, the Lactobacillus genus was most abundant. Putative bacterial pathogens were widespread and often abundant members of the wild mouse gut microbiota. Among a suite of extrinsic (environmental) and intrinsic (host-related) factors examined, seasonal changes dominated in driving qualitative and quantitative differences in the gut microbiota. In both years examined, we observed a strong seasonal shift in gut microbial community structure, potentially due to the transition from an insect- to a seed-based diet. This involved decreased levels of Lactobacillus, and increased levels of Alistipes (Bacteroidetes phylum) and Helicobacter. We also detected more subtle but statistically significant associations between the gut microbiota and biogeography, sex, reproductive status and co-colonization with enteric nematodes. These results suggest that environmental factors have a major role in shaping temporal variations in microbial community structure within natural populations.The ISME Journal advance online publication, 29 May 2015; doi:10.1038/ismej.2015.53.

Original languageEnglish
Pages (from-to)2423–2434
JournalThe ISME Journal
Volume9
Early online date29 May 2015
DOIs
Publication statusPublished - 1 Nov 2015

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