Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm

Jayne L Dennis; Torgeir R Hvidsten; Ernst C Wit; Jan Komorowski; Alexandra K Bell; Ian Downie; Jacqueline Mooney; Caroline Verbeke; Christopher Bellamy; W Nicol Keith; Karin A Oien

doi:10.1158/1078-0432.CCR-04-2236

Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm

Jayne L Dennis, Torgeir R Hvidsten, Ernst C Wit, Jan Komorowski, Alexandra K Bell, Ian Downie, Jacqueline Mooney, Caroline Verbeke, Christopher Bellamy, W Nicol Keith, Karin A Oien

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to enable the assignment of metastases to likely sites of origin on pathologic samples.

Original language	English
Pages (from-to)	3766-72
Number of pages	7
Journal	Clinical Cancer Research
Volume	11
Issue number	10
DOIs	https://doi.org/10.1158/1078-0432.CCR-04-2236
Publication status	Published - 15 May 2005

Keywords / Materials (for Non-textual outputs)

Adenocarcinoma
Biopsy
Diagnosis, Differential
Humans
Immunohistochemistry
In Situ Hybridization
Neoplasms, Unknown Primary
Predictive Value of Tests
Sensitivity and Specificity
Tumor Markers, Biological

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10.1158/1078-0432.CCR-04-2236

Cite this

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title = "Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm",

abstract = "Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to enable the assignment of metastases to likely sites of origin on pathologic samples.",

keywords = "Adenocarcinoma, Biopsy, Diagnosis, Differential, Humans, Immunohistochemistry, In Situ Hybridization, Neoplasms, Unknown Primary, Predictive Value of Tests, Sensitivity and Specificity, Tumor Markers, Biological",

author = "Dennis, {Jayne L} and Hvidsten, {Torgeir R} and Wit, {Ernst C} and Jan Komorowski and Bell, {Alexandra K} and Ian Downie and Jacqueline Mooney and Caroline Verbeke and Christopher Bellamy and Keith, {W Nicol} and Oien, {Karin A}",

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doi = "10.1158/1078-0432.CCR-04-2236",

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T1 - Markers of adenocarcinoma characteristic of the site of origin

T2 - development of a diagnostic algorithm

AU - Dennis, Jayne L

AU - Hvidsten, Torgeir R

AU - Wit, Ernst C

AU - Komorowski, Jan

AU - Bell, Alexandra K

AU - Downie, Ian

AU - Mooney, Jacqueline

AU - Verbeke, Caroline

AU - Bellamy, Christopher

AU - Keith, W Nicol

AU - Oien, Karin A

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to enable the assignment of metastases to likely sites of origin on pathologic samples.

AB - Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to enable the assignment of metastases to likely sites of origin on pathologic samples.

KW - Adenocarcinoma

KW - Biopsy

KW - Diagnosis, Differential

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Neoplasms, Unknown Primary

KW - Predictive Value of Tests

KW - Sensitivity and Specificity

KW - Tumor Markers, Biological

U2 - 10.1158/1078-0432.CCR-04-2236

DO - 10.1158/1078-0432.CCR-04-2236

M3 - Article

C2 - 15897574

SN - 1078-0432

VL - 11

SP - 3766

EP - 3772

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 10

ER -

Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm

Abstract

Keywords / Materials (for Non-textual outputs)

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