Markovnikov-Selective, Activator-Free Iron-Catalyzed Vinylarene Hydroboration

Alistair J. Macnair, Clément R. P. Millet, Gary S. Nichol, Alan Ironmonger, Stephen P. Thomas

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Two series of structurally related alkoxy-tethered NHC iron(II) complexes have been developed as catalysts for the regioselective hydroboration of alkenes. Significantly, Markonikov-selective alkene hydroboration with HBpin has been controllably achieved using an iron catalyst (11 examples, 35–90% isolated yield) with up to 37:1 branched:linear selectivity. anti-Markovnikov-selective alkene hydroboration was also achieved using HBcat and modification of the ligand backbone (6 examples, 44–71% yields). In both cases, ligand design has enabled activator-free low-oxidation-state iron catalysis.
Original languageEnglish
Pages (from-to)7217-7221
JournalACS Catalysis
Early online date22 Sept 2016
Publication statusE-pub ahead of print - 22 Sept 2016


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