Marrow adipose tissue: trimming the fat

Erica Scheller; William Cawthorn; Aaron Burr; Mark C. Horowitz; Ormond A. MacDougald

doi:10.1016/j.tem.2016.03.016

Marrow adipose tissue: trimming the fat

Erica Scheller, William Cawthorn, Aaron Burr, Mark C. Horowitz, Ormond A. MacDougald

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions for
MAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and development of bone metastases. The diversity of these functions highlights the breadth of MAT’s potential impact on health and disease.

Original language	English
Pages (from-to)	392-403
Number of pages	12
Journal	Trends in Endocrinology & Metabolism
Volume	27
Issue number	6
Early online date	16 Apr 2016
DOIs	https://doi.org/10.1016/j.tem.2016.03.016
Publication status	Published - Jun 2016

Keywords / Materials (for Non-textual outputs)

Bone marrow adipose tissue
Adipose tissue
Adipocyte
Bone marrow
Metabolism
Endocrinology
Bone

Access to Document

10.1016/j.tem.2016.03.016

Scheller et al - MAT review - TEM
Author's final peer-reviewed manuscript as accepted for publication
Accepted author manuscript, 5.27 MB

1 Finished

Bone marrow adipose tissue as a novel regulator of metabolic homeostasis
Cawthorn, W.
MRC
1/08/15 → 30/06/22
Project: Research

1 Literature review

Marrow adipose tissue: trimming the fat
Scheller, E., Cawthorn, W., Burr, A., Horowitz, M. C. & MacDougald, O. A., Jun 2016, In: Trends in Endocrinology & Metabolism. 27, 6, p. 392-403 12 p.
Research output: Contribution to journal › Literature review › peer-review

Open Access
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4 Invited talk
2 Participation in conference

Metabolic and endocrine functions of bone marrow adipocytes
Will Cawthorn (Invited speaker)
22 Aug 2019
Activity: Academic talk or presentation types › Invited talk
Endocrine and Metabolic Functions of Bone Marrow Adipose Tissue
Will Cawthorn (Invited speaker)
1 Dec 2018
Activity: Academic talk or presentation types › Invited talk
Basic research on Bone and Cartilage biology
Will Cawthorn (Invited speaker)
5 Oct 2017 → 6 Oct 2017
Activity: Participating in or organising an event types › Participation in conference

Cite this

@article{472df2d2157c495b80e1e0035236a590,

title = "Marrow adipose tissue: trimming the fat",

abstract = "Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions forMAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and development of bone metastases. The diversity of these functions highlights the breadth of MAT{\textquoteright}s potential impact on health and disease.",

keywords = "Bone marrow adipose tissue, Adipose tissue, Adipocyte, Bone marrow, Metabolism, Endocrinology, Bone",

author = "Erica Scheller and William Cawthorn and Aaron Burr and Horowitz, {Mark C.} and MacDougald, {Ormond A.}",

year = "2016",

month = jun,

doi = "10.1016/j.tem.2016.03.016",

language = "English",

volume = "27",

pages = "392--403",

journal = "Trends in Endocrinology & Metabolism",

issn = "1043-2760",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Marrow adipose tissue: trimming the fat

AU - Scheller, Erica

AU - Cawthorn, William

AU - Burr, Aaron

AU - Horowitz, Mark C.

AU - MacDougald, Ormond A.

PY - 2016/6

Y1 - 2016/6

N2 - Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions forMAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and development of bone metastases. The diversity of these functions highlights the breadth of MAT’s potential impact on health and disease.

AB - Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions forMAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and development of bone metastases. The diversity of these functions highlights the breadth of MAT’s potential impact on health and disease.

KW - Bone marrow adipose tissue

KW - Adipose tissue

KW - Adipocyte

KW - Bone marrow

KW - Metabolism

KW - Endocrinology

KW - Bone

U2 - 10.1016/j.tem.2016.03.016

DO - 10.1016/j.tem.2016.03.016

M3 - Literature review

C2 - 27094502

SN - 1043-2760

VL - 27

SP - 392

EP - 403

JO - Trends in Endocrinology & Metabolism

JF - Trends in Endocrinology & Metabolism

IS - 6

ER -

Marrow adipose tissue: trimming the fat

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Bone marrow adipose tissue as a novel regulator of metabolic homeostasis

Research output

Marrow adipose tissue: trimming the fat

Activities

Metabolic and endocrine functions of bone marrow adipocytes

Endocrine and Metabolic Functions of Bone Marrow Adipose Tissue

Basic research on Bone and Cartilage biology

Cite this