Mass spectrometry reveals the assembly pathway of encapsulated ferritins and highlights a dynamic ferroxidase interface

Jennifer Ross, Thomas Lambert, Cecilia Piergentili, Didi He, Kevin J. Waldron, C. Logan Mackay, Jon Marles-wright, David J. Clarke

Research output: Contribution to journalArticlepeer-review

Abstract

Encapsulated ferritins (EncFtn) are a recently characterised member of the ferritin superfamily. EncFtn proteins are sequestered within encapsulin nanocompartments and form a unique biological iron storage system. Here, we use native mass spectrometry and hydrogen–deuterium exchange mass spectrometry to elucidate the metal-mediated assembly pathway of EncFtn.
Original languageEnglish
JournalChemical Communications
Early online date13 Feb 2020
DOIs
Publication statusE-pub ahead of print - 13 Feb 2020

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