Mast cells and vascular diseases

Simon Kennedy, Junxi Wu, Roger M. Wadsworth, Catherine E. Lawrence, Pasquale Maffia

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease. (C) 2013 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalPharmacology and Therapeutics
Volume138
Issue number1
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Mast cell
  • Atherosclerosis
  • Restenosis
  • Aneurysm
  • Vein graft
  • Vascular remodeling
  • ABDOMINAL AORTIC-ANEURYSM
  • SMOOTH-MUSCLE-CELLS
  • E-DEFICIENT MICE
  • SERINE-PROTEASE INHIBITOR
  • II TYPE-1 RECEPTOR
  • FC-EPSILON-RI
  • GASTROINTESTINAL HELMINTH INFECTION
  • PORCINE CORONARY-ARTERIES
  • EXPERIMENTAL VEIN GRAFTS
  • HYPER-IGE SYNDROME

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