Matched population-based study examining the risk of type 2 diabetes in people with and without diagnosed hepatitis C virus infection

Christian Schnier, Sarah Wild, Zain Kurdi, Christopher Povey, DJ Goldberg, SJ Hutchinson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Meta-analyses have found hepatitis C virus (HCV) infection to be associated with an increased risk of type 2 diabetes mellitus (T2DM). Here, we examine this association within a large population-based study, according to RNA status.
A data-linkage approach was used to examine the excess risk of diagnosed T2DM in people diagnosed with HCV-antibodies in Scotland (21,929 Ab+ves; involving 15,827 RNA+ves, 3927 RNA−ves and 2175 with unknown RNA-status) compared to that of a three-fold larger general population sample matched for sex, age and postcode (65,074 Ab−ves). To investigate effects of ascertainment bias the following periods were studied: up to one year before (pre-HCV)/within one year of (peri-HCV)/more than one year post (post-HCV) the date of HCV-diagnosis.
T2DM had been diagnosed in 2.9% of Ab+ves (including 3.2% of RNA+ves and 2.3% of RNA-ves) and 2.7% of Ab−ves. A higher proportion of T2DM was diagnosed in the peri-HCV period (i.e. around the time of HCV-diagnosis) for the Ab+ves (22%) compared to Ab−ves (10%). In both the pre-HCV and post-HCV periods, only those Ab+ves living in less deprived areas (13% of the cohort) were found to have a significant excess risk of T2DM compared to Ab−ves (adjusted odds ratio in the pre-HCV period: 4.0 for females and 2.3 for males; adjusted hazard ratio in the post-HCV period: 1.5). These findings were similarly observed for both RNA+ves (chronic) and RNA−ves (resolved).
In the largest study of T2DM among chronic HCV-infected individuals to date, there was no evidence to indicate that infection conveyed an appreciable excess risk of T2DM at the population level.
Original languageEnglish
JournalJournal of Viral Hepatitis
Early online date22 Feb 2016
DOIs
Publication statusE-pub ahead of print - 22 Feb 2016

Keywords / Materials (for Non-textual outputs)

  • Hepatitis C, Type 2 Diabetes, Matched cohort study, Data linkage

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