TY - JOUR
T1 - Maternal cigarette smoking and effects on androgen action in male offspring
T2 - unexpected effects on second-trimester anogenital distance
AU - Fowler, Paul A
AU - Bhattacharya, Siladitya
AU - Flannigan, Samantha
AU - Drake, Amanda J
AU - O'Shaughnessy, Peter J
PY - 2011
Y1 - 2011
N2 - Fertility, sperm counts, and testis weights are reduced in men whose mothers smoked in pregnancy. Animal studies suggest this could be due to impaired androgen action. Anogenital distance (AGD) provides a readout of fetal androgen exposure and is reduced by in utero exposure to harmful chemicals in rodents. This study assessed whether maternal cigarette smoking disturbs AGD in the second trimester human fetus.
AB - Fertility, sperm counts, and testis weights are reduced in men whose mothers smoked in pregnancy. Animal studies suggest this could be due to impaired androgen action. Anogenital distance (AGD) provides a readout of fetal androgen exposure and is reduced by in utero exposure to harmful chemicals in rodents. This study assessed whether maternal cigarette smoking disturbs AGD in the second trimester human fetus.
U2 - 10.1210/jc.2011-1100
DO - 10.1210/jc.2011-1100
M3 - Article
C2 - 21752894
VL - 96
SP - E1502-6
JO - Journal of Clinical Endocrinology & Metabolism
JF - Journal of Clinical Endocrinology & Metabolism
SN - 0021-972X
IS - 9
ER -