Maternal cigarette smoking and effects on androgen action in male offspring: unexpected effects on second-trimester anogenital distance

Paul A Fowler, Siladitya Bhattacharya, Samantha Flannigan, Amanda J Drake, Peter J O'Shaughnessy

Research output: Contribution to journalArticlepeer-review

Abstract

Fertility, sperm counts, and testis weights are reduced in men whose mothers smoked in pregnancy. Animal studies suggest this could be due to impaired androgen action. Anogenital distance (AGD) provides a readout of fetal androgen exposure and is reduced by in utero exposure to harmful chemicals in rodents. This study assessed whether maternal cigarette smoking disturbs AGD in the second trimester human fetus.
Original languageEnglish
Pages (from-to)E1502-6
JournalJournal of Clinical Endocrinology & Metabolism
Volume96
Issue number9
DOIs
Publication statusPublished - 2011

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