TY - JOUR
T1 - Maternal common mental disorders and infant development in Ethiopia
T2 - the P-MaMiE Birth Cohort
AU - Servili, Chiara
AU - Medhin, Girmay
AU - Hanlon, Charlotte
AU - Tomlinson, Mark
AU - Worku, Bogale
AU - Baheretibeb, Yonas
AU - Dewey, Michael
AU - Alem, Atalay
AU - Prince, Martin
N1 - M1 - 693
PY - 2010/11/12
Y1 - 2010/11/12
N2 - Background: Chronicity and severity of early exposure to maternal common mental disorders (CMD) has been associated with poorer infant development in high-income countries. In low-and middle-income countries (LAMICs), perinatal CMD is inconsistently associated with infant development, but the impact of severity and persistence has not been examined. Methods: A nested population-based cohort of 258 pregnant women was identified from the Perinatal Maternal Mental Disorder in Ethiopia (P-MaMiE) study, and 194 (75.2%) were successfully followed up until the infants were 12 months of age. Maternal CMD was measured in pregnancy and at two and 12 months postnatal using the WHO Self-Reporting Questionnaire, validated for use in this setting. Infant outcomes were evaluated using the Bayley Scales of Infant Development. Results: Antenatal maternal CMD symptoms were associated with poorer infant motor development ((beta) over cap -0.20; 95% CI: -0.37 to -0.03), but this became non-significant after adjusting for confounders. Postnatal CMD symptoms were not associated with any domain of infant development. There was evidence of a dose-response relationship between the number of time-points at which the mother had high levels of CMD symptoms (SRQ >= 6) and impaired infant motor development ((beta) over cap = -0.80; 95% CI -2.24, 0.65 for ante-or postnatal CMD only, (beta) over cap = -4.19; 95% CI -8.60, 0.21 for ante-and postnatal CMD, compared to no CMD; test-for-trend chi(2)13.08(1), p
AB - Background: Chronicity and severity of early exposure to maternal common mental disorders (CMD) has been associated with poorer infant development in high-income countries. In low-and middle-income countries (LAMICs), perinatal CMD is inconsistently associated with infant development, but the impact of severity and persistence has not been examined. Methods: A nested population-based cohort of 258 pregnant women was identified from the Perinatal Maternal Mental Disorder in Ethiopia (P-MaMiE) study, and 194 (75.2%) were successfully followed up until the infants were 12 months of age. Maternal CMD was measured in pregnancy and at two and 12 months postnatal using the WHO Self-Reporting Questionnaire, validated for use in this setting. Infant outcomes were evaluated using the Bayley Scales of Infant Development. Results: Antenatal maternal CMD symptoms were associated with poorer infant motor development ((beta) over cap -0.20; 95% CI: -0.37 to -0.03), but this became non-significant after adjusting for confounders. Postnatal CMD symptoms were not associated with any domain of infant development. There was evidence of a dose-response relationship between the number of time-points at which the mother had high levels of CMD symptoms (SRQ >= 6) and impaired infant motor development ((beta) over cap = -0.80; 95% CI -2.24, 0.65 for ante-or postnatal CMD only, (beta) over cap = -4.19; 95% CI -8.60, 0.21 for ante-and postnatal CMD, compared to no CMD; test-for-trend chi(2)13.08(1), p
U2 - 10.1186/1471-2458-10-693
DO - 10.1186/1471-2458-10-693
M3 - Article
SN - 1471-2458
VL - 10
JO - BMC Public Health
JF - BMC Public Health
ER -