Maternal transmission studies of BSE in sheep

J D Foster, W Goldmann, C McKenzie, A Smith, D W Parnham, N Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

If BSE (bovine spongiform encephalopathy) infected the UK sheep population concurrently with cattle, it would only now be maintained by transmission between sheep by routes which could include from mother to lamb either in utero or via perinatal close contact. In this study of experimental BSE, Cheviot ewes challenged orally with BSE cattle brain produced lambs of various PrP genotypes over the next 7 years. Of 72 surviving to >30 months of age, 29 are of the most susceptible PrP genotype (AQ/AQ) and born to mothers that were challenged with BSE. None of the progeny have shown any signs of disease. The results suggest that in these sheep, BSE could only transmit by the maternal route at a frequency of less than one in four (95 % confidence limit) from clinically affected ewes, a rate which if replicated in other breeds may not be sufficient to maintain BSE within the sheep population.
Original languageEnglish
Pages (from-to)3159-63
Number of pages5
JournalJournal of General Virology
Volume85
Issue numberPt 10
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Animals
  • Cattle
  • Encephalopathy, Bovine Spongiform
  • Female
  • Genotype
  • Infectious Disease Transmission, Vertical
  • Pregnancy
  • Prions
  • Sheep

Fingerprint

Dive into the research topics of 'Maternal transmission studies of BSE in sheep'. Together they form a unique fingerprint.

Cite this