Projects per year
Abstract / Description of output
The model describes the circuit depicted in Fig. 1 of the paper (GIF attached). It updates the Pokhilko et al. 2010 model (termed P2010), PLM_6, by including:
the Evening Complex genes (ELF4, ELF3, LUX),
light-regulated degradation of ELF3 by COP1,
TOC1 as a repressor rather than an activator of LHY/CCA1.
These changes allowed the removal of hypothetical components TOC1mod (or X) and Y from the earlier models. They also reveal that the central loop of the model is a triple-repressor ring oscillator, or 'repressilator' (illustrated in Fig. 8, GIF attached).
Compared to the model version submitted to the Biomodels database, this version slightly alters the names of some variables and uses an SBML AssignmentRule for the light input. This will facilitate the use of a generic SBML StepFunction to better describe the light-dark cycle, in a subsequent version of this model.
|Media of output||SBML model|
|Publication status||Published - 2012|
Keywords / Materials (for Non-textual outputs)
- Biological Clocks
- Circadian Rhythms
- mathematical modeling
- MODEL SIMULATION
- Systems Biology
FingerprintDive into the research topics of 'Mathematical model of the Arabidopsis circadian clock: Pokhilko 2011 model'. Together they form a unique fingerprint.
- 5 Finished
Millar, A., Tindal, C., Muetzelfeldt, R. & Ougham, H.
16/09/08 → 15/09/10
14/04/08 → 13/10/13
Model selection reveals control of cold signalling by evening-phased components of the plant circadian clockKeily, J., MacGregor, D. R., Smith, R. W., Millar, A. J., Halliday, K. J. & Penfield, S., 31 Oct 2013, In: The Plant Journal. 76, 2, p. 247-57 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access
Pokhilko, A., Fernández, A. P., Edwards, K. D., Southern, M. M., Halliday, K. J. & Millar, A. J., 2012, In: Molecular Systems Biology. 8, 574.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile