Mathematical model of the Arabidopsis circadian clock: Pokhilko 2012 model

Alexandra Pokhilko, Andrew Millar

Research output: Other contribution


The model is termed P2012 and derives from the article: Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs. Alexandra Pokhilko, Paloma Mas & Andrew J Millar BMC Syst. Biol. 2013; 7: 23, submitted 10 Oct 2012 and published 19 March 2013.

The model describes the circuit depicted in Fig. 1 of the paper. It updates the P2011 model from Pokhilko et al. Mol. Syst. Biol. 2012 model, PLM_64, by including:

TOC1 as a repressor of multiple clock genes, rather than only of LHY/CCA1.
ABAR transcription modified by TOC1, affecting stomatal aperture.
TOC1 transcription modified by ABA.

SBML curation notes on PlaSMo (please see Comments for each version):

PLM_70 version 1 is the version published as Supplementary Information and submitted to the Biomodels database.

Copasi and MATLAB versions are attached to version 1.

This model has formed the basis for further work by external groups, as described in the following links:
Original languageEnglish
TypeP2012 model
Media of outputDatabase records, various formats
Publication statusPublished - 2013


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