MAVARIC - a comparison of automation-assisted and manual cervical screening: a randomised controlled trial

MAVARIC Trial Study Group, H C Kitchener, R Blanks, H Cubie, M Desai, G Dunn, R Legood, A Gray, Z Sadique, S Moss

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The principal objective was to compare automation-assisted reading of cervical cytology with manual reading using the histological end point of cervical intraepithelial neoplasia grade II (CIN2) or worse (CIN2+). Secondary objectives included (i) an assessment of the slide ranking facility of the Becton Dickinson (BD) FocalPoint™ Slide Profiler (Becton Dickinson, Franklin Lakes, NJ, USA), especially 'No Further Review', (ii) a comparison of the two approved automated systems, the ThinPrep® Imaging System (Hologic, Bedford, MA, USA) and the BD FocalPoint Guided Screener Imaging System, and (iii) automated versus manual in terms of productivity and cost-effectiveness.
Original languageEnglish
Pages (from-to)iii-iv, ix-xi, 1-170
JournalHealth Technology Assessment
Volume15
Issue number3
DOIs
Publication statusPublished - Jan 2011

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Alphapapillomavirus
  • Attitude of Health Personnel
  • Automation, Laboratory
  • Colposcopy
  • Cost-Benefit Analysis
  • Female
  • Great Britain
  • Humans
  • Middle Aged
  • Questionnaires
  • Referral and Consultation
  • Sensitivity and Specificity
  • State Medicine
  • Uterine Cervical Neoplasms
  • Vaginal Smears

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