MaxSynBio: Avenues Towards Creating Cells from the Bottom Up

Petra Schwille*, Joachim Spatz, Katharina Landfester, Eberhard Bodenschatz, Stephan Herminghaus, Victor Sourjik, Tobias J. Erb, Philippe Bastiaens, Reinhard Lipowsky, Anthony Hyman, Peter Dabrock, Jean Christophe Baret, Tanja Vidakovic-Koch, Peter Bieling, Rumiana Dimova, Hannes Mutschler, Tom Robinson, T. Y.Dora Tang, Seraphine Wegner, Kai Sundmacher

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

A large German research consortium mainly within the Max Planck Society (“MaxSynBio”) was formed to investigate living systems from a fundamental perspective. The research program of MaxSynBio relies solely on the bottom-up approach to synthetic biology. MaxSynBio focuses on the detailed analysis and understanding of essential processes of life through modular reconstitution in minimal synthetic systems. The ultimate goal is to construct a basic living unit entirely from non-living components. The fundamental insights gained from the activities in MaxSynBio could eventually be utilized for establishing a new generation of biotechnological processes, which would be based on synthetic cell constructs that replace the natural cells currently used in conventional biotechnology.

Original languageEnglish
Pages (from-to)13382-13392
Number of pages11
JournalAngewandte Chemie - International Edition
Volume57
Issue number41
Early online date17 Sept 2018
DOIs
Publication statusPublished - 4 Oct 2018

Keywords / Materials (for Non-textual outputs)

  • biotechnology
  • bottom-up design
  • microfluidics
  • protocells
  • synthetic biology

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