Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke

Ian Marshall, Bartosz Karaszewski, Joanna M Wardlaw, Vera Cvoro, Karolina Wartolowska, Paul A Armitage, Trevor Carpenter, Mark E Bastin, Andrew Farrall, Kristin Haga

Research output: Contribution to journalArticlepeer-review

Abstract

A magnetic resonance proton spectroscopic imaging (SI) technique was developed to measure regional brain temperatures in human subjects. The technique was validated in a homogeneous phantom and in four healthy volunteers. Simulations and calculations determined the theoretical measurement precision as approximately +/-0.3 degrees C for individual 1-ml voxels. In healthy volunteers, repeated measurements on individual voxels had an S.D. = 1.2 degrees C. In a clinical study, 40 patients with acute ischemic stroke were imaged within 26 h (mean, 10 h) of onset. Temperatures were highest in the region that appeared abnormal (i.e., ischemic) on diffusion-weighted imaging (DWI) compared with a normal-appearing brain. The mean temperature difference between the DWI "lesion" area and the "normal brain" was 0.17 degrees C [P < 10(-3); range, 2.45 degrees C (hotter)-2.17 degrees C (cooler)]. Noninvasive temperature measurement by SI has sufficient precision to be used in studies of pathophysiology in stroke and in other brain disorders and to monitor therapies.

Original languageEnglish
Pages (from-to)699-706
Number of pages8
JournalMagnetic Resonance Imaging
Volume24
Issue number6
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Aged
  • Aged, 80 and over
  • Body Temperature
  • Brain
  • Brain Ischemia
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Phantoms, Imaging
  • Stroke

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