Abstract
A magnetic resonance proton spectroscopic imaging (SI) technique was developed to measure regional brain temperatures in human subjects. The technique was validated in a homogeneous phantom and in four healthy volunteers. Simulations and calculations determined the theoretical measurement precision as approximately +/-0.3 degrees C for individual 1-ml voxels. In healthy volunteers, repeated measurements on individual voxels had an S.D. = 1.2 degrees C. In a clinical study, 40 patients with acute ischemic stroke were imaged within 26 h (mean, 10 h) of onset. Temperatures were highest in the region that appeared abnormal (i.e., ischemic) on diffusion-weighted imaging (DWI) compared with a normal-appearing brain. The mean temperature difference between the DWI "lesion" area and the "normal brain" was 0.17 degrees C [P < 10(-3); range, 2.45 degrees C (hotter)-2.17 degrees C (cooler)]. Noninvasive temperature measurement by SI has sufficient precision to be used in studies of pathophysiology in stroke and in other brain disorders and to monitor therapies.
Original language | English |
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Pages (from-to) | 699-706 |
Number of pages | 8 |
Journal | Magnetic Resonance Imaging |
Volume | 24 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jul 2006 |
Keywords
- Aged
- Aged, 80 and over
- Body Temperature
- Brain
- Brain Ischemia
- Diffusion Magnetic Resonance Imaging
- Female
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Middle Aged
- Phantoms, Imaging
- Stroke