Measuring the Impact of Malaria on the Living Human Retina

Ian James Callum MacCormick, Susan Lewallen, Nicholas A V Beare, Simon Peter Harding

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Retinal examination and imaging are relatively simple methods for studying the dynamic impact of cerebral malaria on the microcirculation of the central nervous system. Retina and brain are affected similarly by Plasmodium falciparum. Unlike the brain, the human retina can be directly observed using commercially available clinical instruments in the setting of a critical care unit, and this can be done repeatedly and non-invasively. Additional information about blood-tissue barriers can be gained from fluorescein angiography. Non-ophthalmologist clinician scientists are usually unfamiliar with ophthalmoscopy and retinal imaging, and some readers may feel that these techniques are beyond them. This chapter aims to quell these fears by providing a step-by-step description of how to examine and photograph the human retina in children with cerebral malaria.

Original languageEnglish
Title of host publicationMalaria Immunology
Subtitle of host publicationTargeting the Surface of Infected Erythrocytes
EditorsAnja Tatiana Ramstedt Jensen, Lars Hviid
Place of PublicationNew York, NY
Pages731-748
Number of pages18
Volume2470
ISBN (Electronic)9781071621899
DOIs
Publication statusPublished - 27 Jul 2022

Publication series

NameMethods in molecular biology (Clifton, N.J.)
PublisherHumana Press
ISSN (Print)1064-3745

Keywords / Materials (for Non-textual outputs)

  • Child
  • Humans
  • Malaria, Cerebral/diagnosis
  • Ophthalmoscopy
  • Plasmodium falciparum
  • Retina
  • Retinal Diseases/diagnosis

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