Mechanical preconditioning enables electrophysiologic coupling of skeletal myoblast cells to myocardium

Klaus Neef, Yeong-Hoon Choi, Sureshkumar Perumal Srinivasan, Philipp Treskes, Douglas B Cowan, Christof Stamm, Martin Rubach, Roland Adelmann, Thorsten Wittwer, Thorsten Wahlers

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of mechanical preconditioning on skeletal myoblasts in engineered tissue constructs was investigated to resolve issues associated with conduction block between skeletal myoblast cells and cardiomyocytes.
Original languageEnglish
Pages (from-to)1176-1184.e1
JournalThe Journal of Thoracic and Cardiovascular Surgery
Volume144
Issue number5
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Action Potentials
  • Animals
  • Animals, Newborn
  • Biological Markers
  • Cadherins
  • Cell Separation
  • Cells, Cultured
  • Coculture Techniques
  • Connexins
  • Desmin
  • Electric Stimulation
  • Excitation Contraction Coupling
  • Gap Junctions
  • Heart
  • Heptanol
  • Mice
  • Mice, Inbred C57BL
  • Muscle Fibers, Skeletal
  • Myoblasts, Skeletal
  • Myocardium
  • Stress, Mechanical
  • Time Factors
  • Tissue Engineering
  • Tissue Scaffolds

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