Mechanism and regulation of the nonsense-mediated decay pathway

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Abstract

The Nonsense-mediated mRNA decay (NMD) pathway
selectively degrades mRNAs harboring premature
termination codons (PTCs) but also regulates
the abundance of a large number of cellular RNAs.
The central role of NMD in the control of gene expression
requires the existence of buffering mechanisms
that tightly regulate the magnitude of this pathway.
Here, we will focus on the mechanism of NMD with
an emphasis on the role of RNA helicases in the transition
from NMD complexes that recognize a PTC to
those that promote mRNA decay. We will also review
recent strategies aimed at uncovering novel transacting
factors and their functional role in the NMD
pathway. Finally, we will describe recent progress in
the study
Original languageEnglish
Pages (from-to)1483-1495
Number of pages13
JournalNucleic Acids Research
DOIs
Publication statusPublished - 14 Jan 2016

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