Mechanism and regulation of the nonsense-mediated decay pathway

Nele Hug; Dagmar Longman; Javier F. Caceres

doi:10.1093/nar/gkw010

Mechanism and regulation of the nonsense-mediated decay pathway

Nele Hug, Dagmar Longman, Javier F. Caceres

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The Nonsense-mediated mRNA decay (NMD) pathway
selectively degrades mRNAs harboring premature
termination codons (PTCs) but also regulates
the abundance of a large number of cellular RNAs.
The central role of NMD in the control of gene expression
requires the existence of buffering mechanisms
that tightly regulate the magnitude of this pathway.
Here, we will focus on the mechanism of NMD with
an emphasis on the role of RNA helicases in the transition
from NMD complexes that recognize a PTC to
those that promote mRNA decay. We will also review
recent strategies aimed at uncovering novel transacting
factors and their functional role in the NMD
pathway. Finally, we will describe recent progress in
the study

Original language	English
Pages (from-to)	1483-1495
Number of pages	13
Journal	Nucleic Acids Research
DOIs	https://doi.org/10.1093/nar/gkw010
Publication status	Published - 14 Jan 2016

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10.1093/nar/gkw010

Mechanism and regulation of the nonsense-mediated decay pathway
© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.36 MBLicence: Creative Commons: Attribution (CC-BY)

CROATIA PROGRAMME
Wright, A., Adams, I., Aligianis, I., Baldock, R., Bickmore, W., Caceres, J., Dorin, J., Dunlop, M., FitzPatrick, D., Haley, C., Hastie, N., Hill, B., Jackson, I., Jackson, A., Kudla, G., Meehan, R., O'Connell, M., Overton, I., Patton, E., Taylor, M., Tenesa, A. & Van Heyningen, V.
MRC
1/04/12 → 31/07/13
Project: Research
RNA BINDING PROTEINS IN HEALTH AND DISEASE
Caceres, J.
UK-based charities
1/10/11 → 31/03/17
Project: Research

Cite this

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title = "Mechanism and regulation of the nonsense-mediated decay pathway",

abstract = "The Nonsense-mediated mRNA decay (NMD) pathwayselectively degrades mRNAs harboring prematuretermination codons (PTCs) but also regulatesthe abundance of a large number of cellular RNAs.The central role of NMD in the control of gene expressionrequires the existence of buffering mechanismsthat tightly regulate the magnitude of this pathway.Here, we will focus on the mechanism of NMD withan emphasis on the role of RNA helicases in the transitionfrom NMD complexes that recognize a PTC tothose that promote mRNA decay. We will also reviewrecent strategies aimed at uncovering novel transactingfactors and their functional role in the NMDpathway. Finally, we will describe recent progress inthe study",

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AU - Caceres, Javier F.

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JO - Nucleic Acids Research

JF - Nucleic Acids Research

ER -

Mechanism and regulation of the nonsense-mediated decay pathway

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CROATIA PROGRAMME

RNA BINDING PROTEINS IN HEALTH AND DISEASE

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