Projects per year
Abstract
Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each kinase has unique structural features that allow their distinct substrate recognition and modes of regulation. These unique regulatory features determine their accurate spatio-temporal activation critical for correct progression through mitosis and are exploited for therapeutic purposes. In this review, we will discuss the principles of mitotic kinase activation and the structural determinants that underlie functional specificity.
Original language | English |
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Pages (from-to) | 6 |
Journal | Frontiers in Cell and Developmental Biology |
Volume | 6 |
DOIs | |
Publication status | Published - 5 Feb 2018 |
Keywords / Materials (for Non-textual outputs)
- Mitotic kinase
- mitosis
- phosphorylation
- structure
- mechanism
- substrate
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Dive into the research topics of 'Mechanisms of Mitotic Kinase Regulation: A Structural Perspective'. Together they form a unique fingerprint.Projects
- 4 Finished
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Molecular Mechanisms of Centromere Inheritance and Kinetochore Function
Arulanandam, J. (Principal Investigator)
4/01/17 → 4/10/22
Project: Research
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Wellcome Centre for Cell Biology
Tollervey, D. (Principal Investigator)
1/12/16 → 1/12/21
Project: Research
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Single molecule studies of microtubule motor complexes
Welburn, J. (Principal Investigator)
1/10/16 → 30/09/17
Project: Research