Mechanisms of Mitotic Kinase Regulation: A Structural Perspective

Research output: Contribution to journalArticlepeer-review


Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each kinase has unique structural features that allow their distinct substrate recognition and modes of regulation. These unique regulatory features determine their accurate spatio-temporal activation critical for correct progression through mitosis and are exploited for therapeutic purposes. In this review, we will discuss the principles of mitotic kinase activation and the structural determinants that underlie functional specificity.

Original languageEnglish
Pages (from-to)6
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 5 Feb 2018


  • Mitotic kinase
  • mitosis
  • phosphorylation
  • structure
  • mechanism
  • substrate

Fingerprint Dive into the research topics of 'Mechanisms of Mitotic Kinase Regulation: A Structural Perspective'. Together they form a unique fingerprint.

Cite this