Mechanisms of Motoric Cognitive Risk – hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining measured slow gait speed and self-reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age. We propose mechanisms on the relationship between motor and cognitive function and describe a roadmap to validate these hypotheses. We systematically searched major electronic databases from inception to August 2021 for original longitudinal cohort studies of adults aged ≥60 years that compared an MCR group to a non-MCR group with any health outcome. Fifteen cohorts were combined by meta-analysis. Participants with MCR were at an increased risk of cognitive impairment (adjusted hazard ratio [aHR] 1.76, 95% CI 1.49–2.08; I 2= 24.9%), dementia (aHR 2.12, 1.85–2.42; 33.1%), falls (adjusted Relative Risk 1.38, 1.15–1.66; 62.1%), and mortality (aHR 1.49, 1.16–1.91; 79.2%). The prognostic value of MCR is considerable and mechanisms underlying the syndrome are proposed.

Original languageEnglish
Pages (from-to)2413-2427
JournalAlzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume18
Issue number12
DOIs
Publication statusPublished - 9 Feb 2022

Keywords / Materials (for Non-textual outputs)

  • dementia
  • falls
  • gait
  • mechanism
  • meta-analysis
  • mortality
  • motoric cognitive risk
  • pathophysiology
  • prevention
  • prognostic
  • review
  • subjective cognitive complaint

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