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Abstract
Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organization and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation of experimental results. Polymer simulations and mechanistic modeling have been applied to explain experimental observations and their links to different aspects of genome function. Here we provide a guide for biologists, explaining different simulation approaches and the contexts in which they have been used.
Original language | English |
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Journal | Nature Methods |
Early online date | 8 Jun 2020 |
DOIs | |
Publication status | E-pub ahead of print - 8 Jun 2020 |
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