Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia

Lisa Genzel*, Martin Dresler, Marion Cornu, Eugen Jaeger, Boris Konrad, Marek Adamczyk, Elisabeth Friess, Axel Steiger, Michael Czisch, Roberto Goya-Maldonado

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Overnight memory consolidation is disturbed in both depression and schizophrenia, creating an ideal situation to investigate the mechanisms underlying sleep-related consolidation and to distinguish disease-specific processes from common elements in their pathophysiology.

METHODS: We investigated patients with depression and schizophrenia, as well as healthy control subjects (each n = 16), under a motor memory consolidation protocol with functional magnetic resonance imaging and polysomnography.

RESULTS: In a sequential finger-tapping task associated with the degree of hippocampal-prefrontal cortex functional connectivity during the task, significantly less overnight improvement was identified as a common deficit in both patient groups. A task-related overnight decrease in activation of the basal ganglia was observed in control subjects and schizophrenia patients; in contrast, patients with depression showed an increase. During the task, schizophrenia patients, in comparison with control subjects, additionally recruited adjacent cortical areas, which showed a decrease in functional magnetic resonance imaging activation overnight and were related to disease severity. Effective connectivity analyses revealed that the hippocampus was functionally connected to the motor task network, and the cerebellum decoupled from this network overnight.

CONCLUSIONS: While both patient groups showed similar deficits in consolidation associated with hippocampal-prefrontal cortex connectivity, other activity patterns more specific for disease pathology differed.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalBiological Psychiatry
Volume77
Issue number2
DOIs
Publication statusPublished - 15 Jan 2015

Keywords

  • Depression
  • fMRI
  • Hippocampus
  • Procedural memory consolidation
  • Schema
  • Schizophrenia
  • Sleep
  • STATE FUNCTIONAL CONNECTIVITY
  • TEMPORAL-LOBE
  • STRUCTURAL CONNECTIVITY
  • NAIVE PATIENTS
  • MOUSE MODEL
  • SLEEP
  • DEFICITS
  • DYSFUNCTION
  • MECHANISMS
  • CORTEX

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