Medroxyprogesterone acetate inhibits the cardioprotective effect of estrogen in experimental ischemia-reperfusion injury

Helen L Jeanes, Payong Wanikiat, Isam Sharif, Gillian A Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Results from recent clinical trials of estrogen and progestogen therapy (EPT) suggest that some progestogens may interfere with the cardiovascular benefits of estrogen (E). The aim of this study was to investigate whether medroxyprogesterone acetate (MPA) modifies the protective effect of E in experimental ischemia-reperfusion (IR) injury in vivo and in vitro in the rat.
Original languageEnglish
Pages (from-to)80-6
Number of pages7
JournalMenopause
Volume13
Issue number1
DOIs
Publication statusPublished - 2006

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