Meiosis I kinase regulators: Conserved orchestrators of reductional chromosome segregation

Stefan Galander, Adele L Marston

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A group of meiosis-specific proteins, namely budding yeast Spo13, fission yeast Moa1,mouse MEIKIN and Drosophila Mtrm, which we call MOKIRs, (meiosis I kinase regulators) are essential for meiotic chromosome segregation. MOKIRs bear no obvious sequence similarity, and yet appear to play functionally conserved roles inregulating meiotic kinases. Meiosis generates haploid gametes from diploid cells through two rounds of chromosome segregation without intervening DNA replication.During meiosis I, homologous chromosomes segregate, reducing chromosome number(reductional division). Conversely, in meiosis II, sister chromatids segregate, similar to mitosis (equational division). Meiosis requires that the cell cycle be re-wired to change both the orientation of kinetochore attachment to microtubules and the timing of sister chromatid cohesion loss. Recent evidence shows that MOKIRs achieve these changes through the spatial and temporal control of key kinases. Here, we review the known roles of MOKIRs and discuss their possible mechanisms of action.
Original languageEnglish
Article number2000018
Early online date6 Aug 2020
Publication statusE-pub ahead of print - 6 Aug 2020

Keywords / Materials (for Non-textual outputs)

  • MOKIRs
  • meiosis
  • spo13
  • moa1
  • matrimony
  • polo kinase


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