Projects per year
A group of meiosis-specific proteins, namely budding yeast Spo13, fission yeast Moa1,mouse MEIKIN and Drosophila Mtrm, which we call MOKIRs, (meiosis I kinase regulators) are essential for meiotic chromosome segregation. MOKIRs bear no obvious sequence similarity, and yet appear to play functionally conserved roles inregulating meiotic kinases. Meiosis generates haploid gametes from diploid cells through two rounds of chromosome segregation without intervening DNA replication.During meiosis I, homologous chromosomes segregate, reducing chromosome number(reductional division). Conversely, in meiosis II, sister chromatids segregate, similar to mitosis (equational division). Meiosis requires that the cell cycle be re-wired to change both the orientation of kinetochore attachment to microtubules and the timing of sister chromatid cohesion loss. Recent evidence shows that MOKIRs achieve these changes through the spatial and temporal control of key kinases. Here, we review the known roles of MOKIRs and discuss their possible mechanisms of action.
- polo kinase
`Core Funding for the Wellcome Trust Centre for Cell Biology¿, Research Enrichment, Public Engagement
1/12/18 → 1/06/22
1/03/16 → 31/08/21