Membrane targeting of core autophagy players during autophagosome biogenesis: Running Title : Recruitment of ATG proteins to the phagophore

Leo J Dudley, Agata N Makar, Noor Gammoh

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Autophagosomes are vital organelles required to facilitate the lysosomal degradation of cytoplasmic cargo, thereby playing an important role in maintaining cellular homeostasis. A number of autophagy-related (ATG) protein complexes are recruited to the site of autophagosome biogenesis where they act to facilitate membrane growth and maturation. Regulated recruitment of ATG complexes to autophagosomal membranes is essential for their autophagic activities and is required to ensure the efficient engulfment of cargo destined for lysosomal degradation. In this review, we discuss our current understanding of the spatiotemporal hierarchy between ATG proteins, examining the mechanisms underlying their recruitment to membranes. A particular focus is placed on the relevance of phosphatidylinositol 3-phosphate (PI(3)P) and the extent to which the core autophagy players are reliant on this lipid for their localisation to autophagic membranes. In addition, open questions and potential future research directions regarding the membrane recruitment and displacement of ATG proteins are discussed here.
Original languageEnglish
JournalThe FEBS Journal
Early online date17 Apr 2020
DOIs
Publication statusE-pub ahead of print - 17 Apr 2020

Keywords / Materials (for Non-textual outputs)

  • autophagy
  • membrane recruitment
  • PI(3)P
  • ATG
  • autophagosome
  • phagophore

Fingerprint

Dive into the research topics of 'Membrane targeting of core autophagy players during autophagosome biogenesis: Running Title : Recruitment of ATG proteins to the phagophore'. Together they form a unique fingerprint.

Cite this