Membrane Voltage Dynamics in Active vs. Passive Mice: The Role of Input Correlations

Miha Pelko, Mark Van Rossum

Research output: Contribution to conferencePosterpeer-review

Abstract

Recent reports of intracellular in-vivo recordings in barrel cortex [1] and primary motor cortex [2] of awake mice reveal two regimes of sub-cellular membrane potential activity and suggest the existence of two distinct network states. In active states, when the mouse is whisking or running, the variance of the sub-threshold membrane voltage decreases and the mean of the membrane voltage increases compared to the passive state when the mouse is not whisking and not moving. Yet the firing rates in both states are comparable.
In this modelling study of a pyramidal cell we explore possible mechanisms behind the two regimes of sub-threshold membrane potential fluctuations. While constraining the total input - the number of presynaptic spikes - we show that the change in the correlation structure of inputs is sufficient to explain the shifts in the mean and the variance of the sub-threshold membrane potential in the two regimes.

References:
[1] James F. A. Poulet and Carl C. H. Petersen, “Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice,” Nature 454, no. 7206 (2008): 881-885.
[2] Puggioni et al., “Layer Specific Sub- and Suprathreshold Coding of Voluntary Movements in the Motor Cortex of Awake Mice”, FENS Forum Abstr.
Original languageEnglish
Publication statusPublished - 2012
Event8th Fens Forum of Neuroscience - Centre Convencions Internacional Barcelona (CCIB) Plaça de Willy Brandt 11-14 08019 Barcelona , Barcelona, Spain
Duration: 14 Jul 201218 Jul 2012

Conference

Conference8th Fens Forum of Neuroscience
CountrySpain
CityBarcelona
Period14/07/1218/07/12

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